Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reversion of cardiovascular remodelling in renovascular hypertensive 2K-1C rats by renin-angiotensin system inhibitors

Full text
Author(s):
do Nascimento Correa, Jose Wilson [1] ; Prado, Cibele Maria [2] ; Riul, Maria Elena [2] ; Araujo, Alice Valenca [3] ; Rossi, Marcos Antonio [2] ; Bendhack, Lusiane Maria [4]
Total Authors: 6
Affiliation:
[1] Fed Univ Amazonas UFAM, Biol Sci Inst, Dept Physiol Sci, Manaus, Amazonas - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, Ribeirao Preto - Brazil
[3] Fed Univ Pernambuco UFPE, Acad Ctr Vitoria CAV, Nucleus Publ Hlth, Vitoria De Santo Antao - Brazil
[4] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology; v. 47, n. 12 AUG 2020.
Web of Science Citations: 0
Abstract

Objectives Evaluate whether the RAS dual blockade would induce additional beneficial effects on cardiovascular remodelling when compared to monotherapy in renal hypertensive two kidneys-one clip (2K-1C) rats. Methods Hypertensive 2K-1C and normotensive (2K) rats were treated for 14 days with submaximal doses of losartan (LOS), enalapril (ENA), losartan plus enalapril (LOS + ENA) or vehicle (water). Blood pressure and some parameters of cardiovascular remodelling were evaluated. Results Systolic blood pressure (SBP) was higher in 2K-1C (209 +/- 3 mm Hg,P < .05) than in 2K (113 +/- 1 mm Hg) rats. There was an additional effect in 2K-1C treated with LOS + ENA (153 +/- 9 mm Hg) on lowering SBP when compared to LOS (184 +/- 12 mm Hg) or ENA (177 +/- 9 mm Hg). None of the treatments had effect on SBP in 2K rats. In 2K-1C, cardiomyocyte hypertrophy was reduced by all treatments, although the cardiac hypertrophy indexes remained unchanged. 2K-1C aortas presented medial thickening that was partially reduced by the treatments. Intimal hyperplasia observed in 2K-1C (15.56 +/- 0.89 mu m vs 8.24 +/- 0.80 mu m) was reversed by ENA (9.52 +/- 0.45 mu m) or LOS + ENA (8.17 +/- 0.53 mu m). Collagen deposition was increased in 2K-1C hearts (1.77 +/- 0.16 vs 1.28 +/- 0.09) and aortas (8.1 +/- 0.6 vs 5.2 +/- 0.2). Treatment with LOS reduced (1.12 +/- 0.14%) and ENA (0.81 +/- 0.11%) or LOS + ENA (0.86 +/- 0.11%) additionally diminished collagen only in 2K-1C hearts. Conclusions Submaximal doses of ACEi and/or ARB have inhibitory actions on cardiac remodelling and vascular hypertrophy not entirely dependent on their effects on blood pressure normalization in renovascular hypertensive rats. Combined therapy produced additional reduction in blood pressure than monotherapy despite a similar inhibition on cardiovascular remodelling. (AU)