| Full text | |
| Author(s): Show less - |
Tahmasebi, Roozbeh
[1, 2]
;
da Costa, Antonio Charlys
[1]
;
Tardy, Kaelan
[1]
;
Tinker, Rory J.
[3]
;
de Padua Milagres, Flavio Augusto
[4, 5, 6, 7]
;
Brustulin, Rafael
[4, 5, 7]
;
Rodrigues Teles, Maria da Aparecida
[4, 6]
;
das Chagas, Rogerio Togisaki
[4, 6]
;
de Deus Alves Soares, Cassia Vitoria
[4, 6]
;
Aranha Watanabe, Aripuana Sakurada
[8]
;
Alencar, Cecilia Salete
[9]
;
Villanova, Fabiola
[10]
;
Deng, Xutao
[11, 12]
;
Delwart, Eric
[11, 12]
;
Luchs, Adriana
[13]
;
Leal, Elcio
[10]
;
Sabino, Ester Cerdeira
[1, 7, 2]
Total Authors: 17
|
| Affiliation: Show less - | [1] Univ Sao Paulo, Inst Trop Med, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Polytech Sch, BR-01246903 Sao Paulo - Brazil
[3] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PL, Lancs - England
[4] Secretary Hlth Tocantins, BR-77453000 Tocantins - Brazil
[5] Fed Univ Tocantins, Inst Biol Sci, BR-77001090 Tocantins - Brazil
[6] Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins - Brazil
[7] Univ Sao Paulo, Fac Med, LIM 46, BR-01246903 Sao Paulo - Brazil
[8] Univ Fed Juiz de Fora, Dept Parasitol Microbiol & Immunol, BR-34092829 Juiz De Fora, MG - Brazil
[9] Univ Sao Paulo, Med Sch, Cent Lab Div DLC HCSP, Lab & LIM 03, Dept Pathol, Clin Hosp, BR-01246000 Sao Paulo - Brazil
[10] Fed Univ, Inst Biol Sci, BR-66075000 Belem, Para - Brazil
[11] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA
[12] Vitalant Res Inst, 270 Masonic Ave, San Francisco, CA 94118 - USA
[13] Adolfo Lutz Inst, Virol Ctr, Enter Dis Lab, BR-01246000 Sao Paulo - Brazil
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | Viruses-Basel; v. 12, n. 5 MAY 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Human Adenovirus species C (HAdV-C) is the most common etiologic agent of respiratory disease. In the present study, we characterized the nearly full-length genome of one potential new HAdV-C recombinant strain constituted by Penton and Fiber proteins belonging to type 89 and a chimeric Hexon protein of types 1 and 89. By using viral metagenomics techniques, we screened out, in the states of Tocantins and Para, Northern and North regions of Brazil, from 2010 to 2016, 251 fecal samples of children between 0.5 to 2.5 years old. These children were presenting acute diarrhea not associated with common pathogens (i.e., rotavirus, norovirus). We identified two HAdV-C strains in two distinct patients. Phylogenetic analysis performed using all complete genomes available at GenBank database indicated that one strain (HAdV-C BR-245) belonged to type 1. The phylogenetic analysis also indicated that the second strain (HAdV-C BR-211) was located at the base of the clade formed by the newly HAdV-C strains type 89. Recombination analysis revealed that strain HAdV-C BR-211 is a chimera in which the variable regions of Hexon gene combined HAdV-C1 and HAdV-C89 sequences. Therefore, HAdV-C BR-211 strain possesses a genomic backbone of type HAdV-C89 and a unique insertion of HAdV-C1 in the Hexon sequence. Recombination may play an important driving force in HAdV-C diversity and evolution. Studies employing complete genomic sequencing on circulating HAdV-C strains in Brazil are needed to understand the clinical significance of the presented data. (AU) | |
| FAPESP's process: | 17/00021-9 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil |
| Grantee: | Antonio Charlys da Costa |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/01735-2 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil |
| Grantee: | Ester Cerdeira Sabino |
| Support Opportunities: | Regular Research Grants |