Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata

Author(s)

Mello, Luiza Costa ^[1] ; da Fonseca, Taina Garcia ^{[1, 2]} ; de Souza, Abessa Denis Moledode ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Ctr Studies Aquat Pollut & Ecoxicol NEPEA, BR-11330900 Sao Vicente, SP - Brazil

^[2] Univ Algarve, Ctr Marine & Environm Res CIMA, Campus Gambelas, P-8000139 Faro - Portugal

• Document type: Journal article
• Source: Marine Pollution Bulletin; v. 159, OCT 2020.
• Web of Science Citations: 0

Abstract

The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents-Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)-on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 +/- 2.42 ng.L-1 (TAM), 27.20 +/- 38.26 ng.L-1 (CisPt), and 101.82 +/- 70.96 ng.L-1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng.L-1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota. (AU)

• FAPESP's process: 18/19123-9 - Development of toxicity test with sandollars Mellita quinquiesperforata eggs for ecotoxicological evaluation of chemotherapics tamoxifen, cisplatin and cyclophosphamide
• Grantee: Luiza Costa Mello
• Support Opportunities: Scholarships in Brazil - Scientific Initiation