Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nuclear Medicine Methods for Assessment of Chronic Chagas Heart Disease

Full text
Author(s):
Marcus Vinicius Simões [1] ; Denise Mayumi Tanaka [2] ; José Antonio Marin-Neto [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo - Brasil
[2] Universidade de São Paulo - Brasil
[3] Universidade de São Paulo - Brasil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Cardiovascular Sciences; v. 33, n. 6, p. 686-696, 2020-11-25.
Abstract

Abstract Several different imaging methods can be used to evaluate patients with Chagas heart disease (CHD) for diagnostic and prognostic purposes, including plain chest radiography; echocardiography; myocardial perfusion scintigraphy, for detection of ischemia and fibrosis; radionuclide gated-angiography, for evaluation of biventricular function; 123I-MIBG labeling of sympathetic myocardial innervation; MRI, for detection and quantitation of myocardial fibrosis; and coronary angiography. This study aims to review the contributions of these nuclear medicine methods to understanding of the pathophysiology of chronic Chagas cardiomyopathy (CCC). Careful analysis and integration of findings provided by these imaging methods in patients with CCC at different stages has contributed significantly to improving understanding of several peculiarities of the disease. Clinical and experimental studies in animal models show that perfusion abnormalities detected in association with dysfunctional but viable myocardium are a common finding in CCC patients and correspond to areas of cardiac sympathetic denervation, as assessed by 123I-MIBG imaging. Furthermore, recent reports have demonstrated a close relationship between coronary microvascular disturbances and myocardial inflammation. Thus, ongoing research, mainly focused on refinements of 18F-FDF -PET techniques and further exploration of nuclear methods, such as SPECT, have the potential to contribute to detection and monitoring of early subclinical myocardial damage thereby enabling evaluation of therapeutic strategies targeting inflammation and microvascular ischemia that could result in better prognostic stratification of patients with CHD. (AU)

FAPESP's process: 16/25403-9 - Investigations on the pathogenesis, pathophysiology and therapy in humans and in an experimental model with the chronic cardiomyopathy of Chagas Disease
Grantee:José Antonio Marin-Neto
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/16450-6 - EFFECTS OF PROLONGED USE OF PENTOXIFILINE OVER MYOCARDIAL PERFUSION CHANGES, ARRYTHMIA EVENTS AND LEFT VENTRICULAR DYSFUNCTION IN THE CHRONIC CHAGAS CARDIOMYOPATHY
Grantee:Marcus Vinicius Simões
Support Opportunities: Regular Research Grants