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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic resveratrol consumption prevents hypertension development altering electrophysiological currents and Ca2+ signaling in chromaffin cells from SHR rats

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Author(s):
Bomfim, Guilherme Henrique Souza [1, 2] ; Musial, Diego Castro [3] ; Mendez-Lopez, Iago [1] ; Jurkiewicz, Aron [3] ; Jurkiewicz, Neide Hyppolito [3] ; Padin, Juan Fernando [4] ; Garcia, Antonio G. [1, 5]
Total Authors: 7
Affiliation:
[1] Univ Autonoma Madrid ITH UAM, Inst Teofilo Hernando, Fac Med, Dept Farmacol & Terapeut, Madrid - Spain
[2] NYU, Coll Dent, Dept Mol Pathobiol, New York, NY 10010 - USA
[3] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Farmacol, Sao Paulo - Brazil
[4] Univ Castilla La Mancha UCLM, Fac Med, Dept Ciencias Med, Ciudad Real - Spain
[5] Univ Autonoma Madrid UAM, Hosp Univ Princesa, Inst Invest Sanitaria, Madrid - Spain
Total Affiliations: 5
Document type: Journal article
Source: CELLULAR SIGNALLING; v. 76, DEC 2020.
Web of Science Citations: 0
Abstract

Resveratrol (RESV) is one of the most abundant polyphenol-stilbene compounds found in red wine with well-established cardioprotective and antihypertensive effects. Hyperactivity of the sympathoadrenal axis seems to be one of the major contributing factors in the pathogenesis of human essential hypertension. Alterations in outward voltage-dependent potassium currents (I-K) and inward voltage-dependent sodium (I-Na), calcium (I-Ca) and nicotinic (I-ACh) currents, CCs excitability, Ca2+ homeostasis, and catecholamine exocytosis were previously related to the hypertensive state. This raised the issue of whether in vivo long-term RESV treatment can directly act as a modulator of Ca2+ influx or a regulator of ion channel permeability in CCs. We monitored outward and inward currents, and cytosolic Ca2+ concentrations ({[}Ca-+(2)](c)) using different pharmacological approaches in CCs from normotensive (WKY) and hypertensive (SHR) animals chronically exposed to trans-RESV (50 mg/L/v.o, 28 days). The long-term RESV treatment prevented the increase of the systolic blood pressure (SBP) in SHR, without reversion of cardiac hypertrophy. We also found an increase of the outward I-K, reduction in inward I-Na, I-Ca, and I-ACh, and the mitigation of {[}Ca2+](c) overload in CCs from SHR at the end of RESV treatment. Our data revealed that electrophysiological alterations of the CCs and in its Ca2+ homeostasis are potential new targets related to the antihypertensive effects of long-term RESV treatment. (AU)

FAPESP's process: 14/01569-0 - Interference of drugs producing disturbances in the drug-receptor interactions in hypertension, hyperglycemia and neurotransmission emphasizing the modulator role of histamine
Grantee:Neide Hyppolito Jurkiewicz
Support Opportunities: Regular Research Grants