| Full text | |
| Author(s): |
Gonzaga, Rodrigo Vieira
[1]
;
do Nascimento, Lucas Adriano
[1]
;
Santos, Soraya Silva
[1]
;
Machado Sanches, Bruna Araujo
[1]
;
Giarolla, Jeanine
[1]
;
Ferreira, Elizabeth Igne
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Av Prof Lineu Prestes 580, Bl 13, BR-05580000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | Journal of Pharmaceutical Sciences; v. 109, n. 11, p. 3262-3281, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Self-immolative drug delivery system is one of the delivery systems, which have drawn attention, in recent research, highlighting the improvement they generate in drug selectivity and efficacy. Self-immolative linkers, or spacers, are covalent groups, which have the role of cleavaging two bonds between a protector group and a drug, in the case of drug delivery systems, after a stimuli. The cascade of reactions allows to control the release of the drug. The choice of the adequate self-immolative linker is essential and depend on many variables and goals as well. Many approaches can be explored when designing a system adequate for achieving these goals, especially prodrugs. Some of the most used stimuli-responses for self-immolative drugs - enzyme triggers, chemical triggers, as pH, redox system, 1,4-, 1,6-, 1,8-eliminations, photodegradable triggers, multiple triggers, among others - are described in this ten-year review, along with their application as theranostic agents. We intend that the examples presented in this review inspire researchers working on drug delivery systems to further explore their application. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved. (AU) | |