A New Take on Prion Protein Dynamics in Cellular Trafficking

Author(s)

Alves, Rodrigo Nunes ^[1] ; Iglesia, Rebeca Piatniczka ^[1] ; Prado, Mariana Brandao ^[1] ; Melo Escobar, Maria Isabel ^[1] ; Boccacino, Jacqueline Marcia ^[1] ; Fernandes, Camila Felix de Lima ^[1] ; Coelho, Barbara Paranhos ^[1] ; Fortes, Ailine Cibele ^[1] ; Lopes, Marilene Hohmuth ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo - Brazil

• Document type: Review article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 20 OCT 2020.
• Web of Science Citations: 0

Abstract

The mobility of cellular prion protein (PrP) in specific cell membrane domains and among distinct cell compartments dictates its molecular interactions and directs its cell function. PrP works in concert with several partners to organize signaling platforms implicated in various cellular processes. The scaffold property of PrP is able to gather a molecular repertoire to create heterogeneous membrane domains that favor endocytic events. Dynamic trafficking of PrP through multiple pathways, in a well-orchestrated mechanism of intra and extracellular vesicular transport, defines its functional plasticity, and also assists the conversion and spreading of its infectious isoform associated with neurodegenerative diseases. In this review, we highlight how PrP traffics across intra- and extracellular compartments and the consequences of this dynamic transport in governing cell functions and contributing to prion disease pathogenesis. (AU)

• FAPESP's process: 20/07450-5 - Evaluation of transcript levels of PrPc downstream targets and intracellular signaling pathways in glioblastoma stem cells
• Grantee: Jacqueline Marcia Boccacino
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/26158-0 - Prion protein as stem regulator in glioblastoma stem cells: its role in the formation and function of multiprotein signaling platforms
• Grantee: Mariana Brandão Prado
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/14952-0 - Characterization of intracellular signaling pathways modulated by the cellular prion protein on stemness maintenance in glioblastoma stem cells
• Grantee: Bárbara Paranhos Coelho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs
• Grantee: Maria Isabel Melo Escobar
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 20/04687-4 - The role of neural stem cells extracellular vesicles in the modulation of phenotype of PRNP low and PRNP high glioblastoma stem cells
• Grantee: Rodrigo Nunes Alves
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy
• Grantee: Marilene Hohmuth Lopes
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 19/12710-9 - Role of cellular prion protein in temozolomide resistance: emphasis on processes modulated by hypoxia
• Grantee: Rebeca Piatniczka Iglesia
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/14741-9 - Study of the role of STI1 and assotiated factors in the proteostasis network and pluripotency regulation
• Grantee: Camila Felix de Lima Fernandes
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)