| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Lab Comparat & Translat Oncol LOCT, Pirassununga - Brazil
[2] Goethe Univ Frankfurt, Struct Genom Consortium, Buchmann Inst Mol Life Sci, Frankfurt - Germany
[3] Goethe Univ Frankfurt, Inst Pharmaceut Chem, Buchmann Inst Mol Life Sci, Frankfurt - Germany
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN ONCOLOGY; v. 10, OCT 23 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells. (AU) | |
| FAPESP's process: | 19/05778-6 - Combined inhibition of BET proteins AND HDACs as an effective strategy for the treatment of mammary cancer: a comparative study |
| Grantee: | Pedro Luiz Porfirio Xavier |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/11966-4 - Epigenetic modulations and self-renewal potential of canine mammary cancer cells: the search for potential therapeutic targets |
| Grantee: | Pedro Luiz Porfirio Xavier |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/02493-7 - Mammary tumors of dogs and the cancer stem cell theory: a comparative and translational approach |
| Grantee: | Heidge Fukumasu |
| Support Opportunities: | Research Grants - Young Investigators Grants |