| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508000 Sao Paulo - Brazil
[2] Albert Einstein Coll Med, Div Infect Dis, Dept Med, New York, NY 10461 - USA
[3] Albert Einstein Coll Med, Div Infect Dis, Dept Microbiol & Immunol, New York, NY 10461 - USA
[4] Univ Sao Paulo, Fac Med, Dept Dermatol, Inst Med Trop Sao Paulo, Lab Micol Med, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | JOURNAL OF FUNGI; v. 6, n. 3 SEP 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Vaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccine for fungi is a problem of increasing importance as the incidence of diverse species, including Paracoccidioides, Aspergillus, Candida, Sporothrix, and Coccidioides, has increased in recent decades and new drug-resistant pathogenic fungi are emerging. In fact, our antifungal armamentarium too frequently fails to effectively control or cure mycoses, leading to high rates of mortality and morbidity. With this in mind, many groups are working towards identifying effective and safe vaccines for fungal pathogens, with a particular focus of generating vaccines that will work in individuals with compromised immunity who bear the major burden of infections from these microbes. In this review, we detail advances in the development of vaccines for pathogenic fungi, and highlight new methodologies using immunoproteomic techniques and bioinformatic tools that have led to new vaccine formulations, like peptide-based vaccines. (AU) | |
| FAPESP's process: | 16/08730-6 - Fungal pathogenicity: environmental effects, immune response and vaccine modulation in the Brazilian endemic mycoses paracoccidioidomycosis and histoplasmosis |
| Grantee: | Carlos Pelleschi Taborda |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/20622-2 - Prospection of new epitopes antigenic from P. lutzii isolate with vaccine potential |
| Grantee: | Leandro Buffoni Roque da Silva |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 18/25171-6 - Prospection of new epitopes with vaccine potential in the control of experimental infection by Paracoccidioides lutzii |
| Grantee: | Leandro Buffoni Roque da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |