Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis

Author(s)

Maginador, Guilherme ^[1] ; Lixandrao, Manoel E. ^[2] ; Bortolozo, Henrique I. ^[1] ; Vechin, Felipe C. ^[2] ; Sarian, Luis O. ^[1] ; Derchain, Sophie ^[1] ; Telles, Guilherme D. ^[2] ; Zopf, Eva ^[3] ; Ugrinowitsch, Carlos ^[2] ; Conceicao, Miguel S. ^{[2, 1, 4]}

Affiliation

^[1] Univ Estadual Campinas, Dept Obstet & Gynecol, Fac Med Sci, BR-13083881 Campinas, SP - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

^[3] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Dept Exercise Oncol, Melbourne, Vic 3000 - Australia

^[4] Univ Estadual Campinas, Fac Phys Educ, BR-13083851 Campinas - Brazil

• Document type: Review article
• Source: CANCERS; v. 12, n. 8 AUG 2020.
• Web of Science Citations: 0

Abstract

While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or interval) on changes in CRF in women with breast cancer (BC) receiving chemotherapy. A systematic review and meta-analysis were conducted as per PRISMA guidelines, and randomized controlled trials comparing usual care (UC) and aerobic training in women with BC undergoing chemotherapy were eligible. The results suggest that increases in CRF are favored by (a) aerobic training when compared to usual care; (b) vigorous-intensity aerobic exercise (64-90% of maximal oxygen uptake, VO2max) when compared to moderate-intensity aerobic exercise (46-63% of VO2max); and (c) both continuous and interval aerobic training are effective at increasing the VO2max. Aerobic training improves CRF in women with BC undergoing chemotherapy. Notably, training intensity significantly impacts the VO(2max)response. Where appropriate, vigorous intensity aerobic training should be considered for women with BC receiving chemotherapy. (AU)

• FAPESP's process: 15/19756-3 - Effects of concurrent training on muscle satellite cells and myofibrillar protein synthesis
• Grantee: Miguel Soares Conceição
• Support Opportunities: Scholarships in Brazil - Post-Doctoral