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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

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de Paiva, Raphael E. F. [1] ; Neto, Antonio Marcal [2] ; Santos, Igor A. [3] ; Jardim, Ana C. G. [3] ; Corbi, Pedro P. [4] ; Bergamini, Fernando R. G. [2]
Total Authors: 6
[1] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Uberlandia, Inst Chem, Lab Synth Bioinspired Mol, BR-38400902 Uberlandia, MG - Brazil
[3] Univ Fed Uberlandia, Inst Biomed Sci, Lab Virol, BR-38405302 Uberlandia, MG - Brazil
[4] Univ Estadual Campinas, Inst Chem, BR-13083871 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: DALTON TRANSACTIONS; v. 49, n. 45, p. 16004-16033, DEC 7 2020.
Web of Science Citations: 1

In light of the Covid-19 outbreak, this review brings together historical and current literature efforts towards the development of antiviral metallodrugs. Classical compounds such as CTC-96 and auranofin are discussed in depth, as pillars for future metallodrug development. From the recent literature, both cell-based results and biophysical assays against potential viral biomolecule targets are summarized here. The comprehension of the biomolecular targets and their interactions with coordination compounds are emphasized as fundamental strategies that will foment further development of metal-based antivirals. We also discuss other possible and unexplored methods for unveiling metallodrug interactions with biomolecules related to viral replication and highlight the specific challenges involved in the development of antiviral metallodrugs. (AU)

FAPESP's process: 18/12062-4 - Synthesis, characterization and studies of interaction with biomolecules of metal complexes containing biologically active ligands: a strategy in the preparation of new agents with antibacterial and antiviral activities
Grantee:Pedro Paulo Corbi
Support type: Regular Research Grants
FAPESP's process: 18/21537-6 - Polydentate imine ligands as modulators of copper reactivity in inflammation-related diseases and in bioorthogonal coupling reactions
Grantee:Raphael Enoque Ferraz de Paiva
Support type: Scholarships in Brazil - Post-Doctorate