Early impairment of myocardial deformation assessed by regional speckle-tracking echocardiography in the indeterminate form of Chagas disease without fibrosis detected by cardiac magnetic resonance

Author(s)

Romano, Minna Moreira Dias ^[1] ; Moreira, Henrique Turin ^[1] ; Marin-Neto, Jose Antonio ^[1] ; Baccelli, Priscila Elias ^[1] ; Alenezi, Fawaz ^[2] ; Klem, Igor ^[2] ; Maciel, Benedito Carlos ^[1] ; Kisslo, Joseph ^[2] ; Schmidt, Andre ^[1] ; Velazquez, Eric J. ^{[2, 3]}

Affiliation

^[1] Univ Sao Paulo, Dept Internal Med, Med Sch Ribeirao Preto, Ctr Cardiol, Sao Paulo - Brazil

^[2] Duke Univ, Sch Med, Dept Med, Cardiol, Durham, NC 27706 - USA

^[3] Yale Sch Med, Cardiovasc Med, New Haven, CT - USA

• Document type: Journal article
• Source: PLoS Neglected Tropical Diseases; v. 14, n. 11 NOV 2020.
• Web of Science Citations: 0

Abstract

Chagas disease (CD) will account for 200,000 cardiovascular deaths worldwide over the next 5 years. Early detection of chronic Chagas cardiomyopathy (CCC) is a challenge. We aimed to test if speckle-tracking echocardiography (STE) can detect incipient myocardial damage in CD. METHODS: Among 325 individuals with positive serological tests, 25 (age 55 +/- 12yrs) were selected to compose the group with indeterminate form of Chagas disease (IFCD), based on stringent criteria of being asymptomatic and with normal EKG/X-ray studies. This group was compared with a group of 20 patients with CCC (55 +/- 11yrs) and a group of 20 non-infected matched control (NC) subjects (48 +/- 10yrs). CD patients and NC were submitted to STE and CD patients were submitted to cardiac magnetic resonance (CMR) with late gadolinium administration to detect cardiac fibrosis by the late enhancement technique. Global longitudinal strain (GLS), circumferential (GCS) and radial strain (GRS) were defined as the average of segments measured from three apical view (GLS) and short axis views (GRS and GCS). Regional left ventricular (LV) longitudinal strain (Reg LS) was measured from each of the 17 segments. Twist was measured as systolic peak difference between basal and apical rotation and indexed to LV length to express torsion. RESULTS: STE global indices (GLS, GCS, twist and torsion) were reduced in CCC vs NC (GLS: -14 +/- 6.3% vs -19.3 +/- 1.6%, p = 0.001; GCS: -13.6 +/- 5.2% vs -17.3 +/- 2.8%; p = 0.008; twist: 8 +/- 7 degrees vs 14 +/- 7 degrees, p = 0.01 and torsion: 0.96 +/- 1 degrees/cm vs 1.9 +/- 1 degrees/cm, p = 0.005), but showed no differences in IFCD vs NC. RegLS was reduced in IFCD vs NC in four LV segments: basal-inferior (-16.3 +/- 3.3% vs -18.6 +/- 2.2%, p = 0.013), basal inferoseptal (-13.1 +/- 3.4 vs -15.2 +/- 2.7, p = 0.019), mid-inferoseptal (-17.7 +/- 3.2 vs -19.4 +/- 2, p = 0.032) and mid-inferolateral (-15.2 +/- 3.5 vs -17.8 +/- 2.8, p = 0.014). These abnormalities in RegLS occurred in the absence of myocardial fibrosis detectable with CMR in nearly 92% of subjects with IFCD, while myocardial fibrosis was present in 65% with CCC. CONCLUSION: RegLS detects early regional impairment of myocardial strain that is independent from fibrosis in IFCD subjects. Author summary Regional longitudinal strain is reduced in IFCD before significant fibrosis. As CD progresses to CF, global STE measurements of left ventricle (GLS, GCS, twist and torsion) and GLS of right ventricle are reduced. Early abnormal strain pattern of CD comprises inferior, septoinferior and inferolateral segments of LV. Recognizing the regional strain pattern of Chagas cardiomyopathy may help identifying the disease even at early stages. (AU)

• FAPESP's process: 16/25403-9 - Investigations on the pathogenesis, pathophysiology and therapy in humans and in an experimental model with the chronic cardiomyopathy of Chagas Disease
• Grantee: José Antonio Marin-Neto
• Support Opportunities: Research Projects - Thematic Grants