Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

Author(s)

Figueiredo, Mariana Pires ^{[1, 2, 3]} ; Borrego-Sanchez, Ana ^{[2, 3]} ; Garcia-Villen, Fatima ^[2] ; Miele, Dalila ^[4] ; Rossi, Silvia ^[4] ; Sandri, Giuseppina ^[4] ; Viseras, Cesar ^{[2, 3]} ; Constantino, Vera Regina Leopoldo ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil

^[2] Univ Granada UGR, Dept Pharm & Pharmaceut Technol, Fac Pharm, Campus Cartuja S-N, Granada 18071 - Spain

^[3] Univ Granada, Andalusian Inst Earth Sci, Consejo Super Invest Cient, Ave Palmeras 4, Granada 18100 - Spain

^[4] Univ Pavia, Dept Drug Sci, Viale Taramelli 12, I-27100 Pavia - Italy

• Document type: Journal article
• Source: PHARMACEUTICS; v. 12, n. 11 NOV 2020.
• Web of Science Citations: 0

Abstract

This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH-polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings. (AU)

• FAPESP's process: 18/22782-4 - Pharmacological studies of advanced surgical devices based on layered double hydroxides polymer composites
• Grantee: Mariana Pires Figueiredo
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)