Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Minisci C-H Alkylation of Heteroarenes Enabled by Dual Photoredox/Bromide Catalysis in Micellar Solutions

Full text
Author(s):
Santos, Marilia S. [1] ; Cybularczyk-Cecotka, Martyna [2] ; Koenig, Burkhard [1] ; Giedyk, Maciej [2]
Total Authors: 4
Affiliation:
[1] Univ Regensburg, Fac Chem & Pharm, Univ Str 31, D-93053 Regensburg - Germany
[2] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw - Poland
Total Affiliations: 2
Document type: Journal article
Source: CHEMISTRY-A EUROPEAN JOURNAL; v. 26, n. 66, p. 15323-15329, NOV 26 2020.
Web of Science Citations: 0
Abstract

Aromatic heterocycles are omnipresent structural motifs in various natural products, pharmaceuticals and agrochemicals. This work describes a photocatalytic Minisci-type C-H functionalization of heteroarenes with non-activated alkyl bromides. The reaction avoids stoichiometric radical-promoters, oxidants, or acids, and is conducted using blue LEDs as the light source. The reactive carbon-centered alkyl radicals are generated by merging the photoredox approach with bromide anion co-catalysis and spatial pre-aggregation of reacting species in the micellar aqueous solutions. The obtained data highlight the critical importance of microstructuring and organization of the components in the reaction mixture. (AU)

FAPESP's process: 18/20956-5 - C-H Functionalization of Aliphatic and Aromatic Heterocycles by Visible Light Photoredox Catalysis
Grantee:Marília Simão dos Santos
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor