| Full text | |
| Author(s): Show less - |
Minuzzi, Luciele Guerra
[1, 2, 3]
;
da Conceicao, Luciana Renata
[1]
;
Munoz, Vitor Rosetto
[1]
;
Vieira, Renan Fudoli Lins
[1]
;
Gaspar, Rafael Calais
[1]
;
da Silva, Adelino S. R.
[4]
;
Cintra, Dennys Esper
[5, 6]
;
de Moura, Leandro Pereira
[7, 1, 6]
;
Ropelle, Eduardo Rochete
[7, 1, 6]
;
Teixeira, Ana Maria
[2]
;
Pauli, Jose Rodrigo
[7, 1, 6]
Total Authors: 11
|
| Affiliation: | [1] Univ Campinas UNICAMP, Lab Mol Biol Exercise LaBMEx, Sao Paulo - Brazil
[2] Univ Coimbra Res, Ctr Sport & Phys Act, Fac Sport Sci & Phys Educ, Coimbra - Portugal
[3] Sao Paulo State Univ UNESP, Exercise & Immunometab Res Grp, Postgrad Program Movement Sci, Dept Phys Educ, Presidente Prudente, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Sao Paulo - Brazil
[5] Univ Campinas UNICAMP, Lab Nutr Genom LabGeN, Sao Paulo - Brazil
[6] Univ Estadual Campinas, Lab Cell Signalling, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[7] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Sao Paulo - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | CYTOKINE; v. 137, JAN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Purpose: Interleukin-15 (IL-15) is a myokine that has been proposed to modulate skeletal muscle and adipose tissue mass, as well as insulin sensitivity. However, the evidence suggesting a role for IL-15 in improving whole body insulin sensitivity and decreasing adiposity comes mainly from studies using supraphysiological levels of this cytokine. This study examined the effect of a short-term exercise training protocol on the protein content of IL-15, it's signaling pathway, and glucose tolerance in aged rats. Methods: Fourteen Wistar rats were divided into Young Sedentary (Young, n = 4); Old Sedentary (Old, n = 5); Old Exercise (Old.Exe, n = 5) groups. The animals from the exercised group were submitted to a short-term physical exercise protocol for five days. At the end of physical training and after 16 h of the last exercise session, the animals were euthanized, and tissue collection was done. Results: Physical exercise decreased epididymal and mesenteric fat mass and promoted positive effects on glucose tolerance and insulin sensitivity. Muscle IL-15 protein levels were not changed following the short-term physical exercise training with no alterations in the post-exercise IL-15-JAK/STAT signaling pathway. We found a tendency to increased HIF1 alpha and a significant increase in its regulator, PHD2, in the skeletal muscle after exercise. Conclusion: The elderly rats submitted to short-term aerobic physical training did not present skeletal muscle alteration in the protein content of the IL-15 and IL-15-JAK/STAT signaling pathway. However, short-term aerobic physical training was able to modulate the expression of HIF1 alpha and its regulator PHD2, suggesting an essential role of these proteins in improving post-exercise glucose tolerance and insulin sensitivity in elderly rats. (AU) | |
| FAPESP's process: | 18/20872-6 - Effects of physical exercise on Rock protein signaling pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats |
| Grantee: | José Rodrigo Pauli |
| Support Opportunities: | Regular Research Grants |