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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats

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Minuzzi, Luciele Guerra [1, 2, 3] ; da Conceicao, Luciana Renata [1] ; Munoz, Vitor Rosetto [1] ; Vieira, Renan Fudoli Lins [1] ; Gaspar, Rafael Calais [1] ; da Silva, Adelino S. R. [4] ; Cintra, Dennys Esper [5, 6] ; de Moura, Leandro Pereira [7, 1, 6] ; Ropelle, Eduardo Rochete [7, 1, 6] ; Teixeira, Ana Maria [2] ; Pauli, Jose Rodrigo [7, 1, 6]
Total Authors: 11
Affiliation:
[1] Univ Campinas UNICAMP, Lab Mol Biol Exercise LaBMEx, Sao Paulo - Brazil
[2] Univ Coimbra Res, Ctr Sport & Phys Act, Fac Sport Sci & Phys Educ, Coimbra - Portugal
[3] Sao Paulo State Univ UNESP, Exercise & Immunometab Res Grp, Postgrad Program Movement Sci, Dept Phys Educ, Presidente Prudente, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Sao Paulo - Brazil
[5] Univ Campinas UNICAMP, Lab Nutr Genom LabGeN, Sao Paulo - Brazil
[6] Univ Estadual Campinas, Lab Cell Signalling, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[7] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: CYTOKINE; v. 137, JAN 2021.
Web of Science Citations: 0
Abstract

Purpose: Interleukin-15 (IL-15) is a myokine that has been proposed to modulate skeletal muscle and adipose tissue mass, as well as insulin sensitivity. However, the evidence suggesting a role for IL-15 in improving whole body insulin sensitivity and decreasing adiposity comes mainly from studies using supraphysiological levels of this cytokine. This study examined the effect of a short-term exercise training protocol on the protein content of IL-15, it's signaling pathway, and glucose tolerance in aged rats. Methods: Fourteen Wistar rats were divided into Young Sedentary (Young, n = 4); Old Sedentary (Old, n = 5); Old Exercise (Old.Exe, n = 5) groups. The animals from the exercised group were submitted to a short-term physical exercise protocol for five days. At the end of physical training and after 16 h of the last exercise session, the animals were euthanized, and tissue collection was done. Results: Physical exercise decreased epididymal and mesenteric fat mass and promoted positive effects on glucose tolerance and insulin sensitivity. Muscle IL-15 protein levels were not changed following the short-term physical exercise training with no alterations in the post-exercise IL-15-JAK/STAT signaling pathway. We found a tendency to increased HIF1 alpha and a significant increase in its regulator, PHD2, in the skeletal muscle after exercise. Conclusion: The elderly rats submitted to short-term aerobic physical training did not present skeletal muscle alteration in the protein content of the IL-15 and IL-15-JAK/STAT signaling pathway. However, short-term aerobic physical training was able to modulate the expression of HIF1 alpha and its regulator PHD2, suggesting an essential role of these proteins in improving post-exercise glucose tolerance and insulin sensitivity in elderly rats. (AU)

FAPESP's process: 18/20872-6 - Effects of physical exercise on Rock protein signaling pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats
Grantee:José Rodrigo Pauli
Support Opportunities: Regular Research Grants