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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents

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Author(s):
Freitas, Emanuelle D. [1] ; Freitas, Vitoria M. S. [1] ; Rosa, Paulo C. P. [2] ; da Silva, Meuris G. C. [1] ; Vieira, Melissa G. A. [1]
Total Authors: 5
Affiliation:
[1] Univ Campinas UNICAMP, Sch Chem Engn, Albert Einstein Ave 500, BR-13083852 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, Candido Portinari St, BR-13083871 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 118, JAN 2021.
Web of Science Citations: 2
Abstract

Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen. Sericin has been shown to be essential for improving incorporation efficiency. Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (> 80%) and drug loading capacity (> 20%). In this case, delayed release (< 10% in acid medium) and prolonged release (similar to 360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation. The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix. In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug. (AU)

FAPESP's process: 15/13505-9 - INCORPORATION AND RELEASE OF DRUGS BY SERICIN-ALGINATE MICROPARTICLES
Grantee:Melissa Gurgel Adeodato Vieira
Support Opportunities: Regular Research Grants
FAPESP's process: 16/05007-1 - Removal of residual drug in aqueous solution by alternative adsorbents
Grantee:Meuris Gurgel Carlos da Silva
Support Opportunities: Regular Research Grants