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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid hormones, Sertoli cell proliferation and differentiation in progenies from carbamazepine-treated rat dams during pregnancy and lactation

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Author(s):
Oliva, Samara U. [1] ; Andretta, Rhaiza R. [1] ; Simas, Joana N. [1] ; Tesser, Renato B. [2] ; Paccola, Camila C. [1] ; Miraglia, Sandra M. [1]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Dev Biol Lab, Sao Paulo - Brazil
[2] Ctr Univ Sao Camilo, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ANDROLOGIA; v. 53, n. 3 JAN 2021.
Web of Science Citations: 0
Abstract

Carbamazepine (CBZ) is used in the control of seizure and affective disorders, causing hypothyroidism. Thyroid hormones regulate the Sertoli cell proliferation and differentiation. Clinical aspects must be considered since epileptic fertile women need to continuously use CBZ during pregnancy and lactation. This study aimed to evaluate the effects of CBZ on testis development of rat offspring from dams treated during pregnancy/lactation. Rat dams received CBZ (20 mg kg(-1) day(-1)) or vehicle by intra-peritoneal route during gestation and lactation. Progenies were euthanised at 4, 14, 41, 63 and 93-days post-partum (dpp) for the evaluation of T3, T4 and TSH plasma total levels. Testicular cross sections were submitted to anti-Ki67, anti-PCNA, anti-p27(kip1) and anti-transferrin immunolabelling for the evaluation of Sertoli cells. There was a significant reduction in p27(kip1)-positive Sertoli cell numerical densities and an increase in TSH level at 14 dpp. CBZ exposure affected the volume density of transferrin-positive immunolabelling at 63 dpp. These results suggest that CBZ may cause a dysregulation of the controller system of thyroid hormones homeostasis leading to an increase in the proliferation rate at the neonatal phase and a differentiation delay of the Sertoli cell, culminating in an altered function at late puberty. The occurrence of hypothyroidism cannot be completely discarded. (AU)

FAPESP's process: 12/05905-9 - Role of thyroid hormones on Sertoli cell proliferation and differentiation and on sperm production of progeny from carbamazepine treated-rats during the pregnancy and lactation
Grantee:Sandra Maria Miraglia Valdeolivas
Support Opportunities: Regular Research Grants