The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells

Author(s)

Castro, Kelly A. D. F. ^{[1, 2]} ; Costa, Leticia D. ^[2] ; Prandini, Juliana A. ^[1] ; Biazzotto, Juliana C. ^[1] ; Tome, Augusto C. ^[2] ; Hamblin, Michael R. ^[3] ; da Graca P. M. S. Neves, Maria ^[2] ; Faustino, M. Amparo F. ^[2] ; da Silva, Roberto S. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto, SP - Brazil

^[2] Univ Aveiro, Dept Chem, LAQV REQUIMTE, Aveiro - Portugal

^[3] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein - South Africa

• Document type: Journal article
• Source: CHEMISTRY-A EUROPEAN JOURNAL; v. 27, n. 6 JAN 2021.
• Web of Science Citations: 0

Abstract

Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen (O-1(2)) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells. (AU)

• FAPESP's process: 16/12707-0 - Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug
• Grantee: Roberto Santana da Silva
• Support Opportunities: Regular Research Grants