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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

NAPROXEN/LAYERED DOUBLE HYDROXIDE COMPOSITES FOR TISSUE-ENGINEERING APPLICATIONS: PHYSICOCHEMICAL CHARACTERIZATION AND BIOLOGICAL EVALUATION

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Author(s):
Bernardo, Marcela P. [1] ; Rodrigues, Bruna C. S. [1] ; de Oliveira, Tamires D. [2] ; Guedes, Adriana P. M. [2] ; Batista, Alzir A. [2] ; Mattoso, Luiz H. C. [1]
Total Authors: 6
Affiliation:
[1] Brazilian Agr Res Corp, Embrapa Instrumentat, Natl Nanotechnol Lab Agribusiness, Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLAYS AND CLAY MINERALS; v. 68, n. 6 JAN 2021.
Web of Science Citations: 0
Abstract

Injured bone tissues can be healed with bone grafts, but this procedure may cause intense pain to the patient. A slow and localized delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) could help to reduce the pain without affecting bone regeneration. The objective of the present study was to use {[}Mg-Al]-layered double hydroxide (LDH) as a matrix for controlled release of sodium naproxen (NAP). This system could be applied in biomaterial formulations (such as bone grafts) to achieve a local delivery of naproxen. {[}Mg-Al]-LDH successfully incorporated up to 80% (w/w) of naproxen by the structural reconstruction route, with the {[}Mg-Al]-LDH interlayer space increasing by 0.55 nm, corresponding to the drug molecule size. The evaluation of the naproxen release kinetics showed that 40% of the drug was delivered over 48 h in aqueous medium (pH 7.4 +/- 0.1), indicating the potential of {[}Mg-Al]-LDH/NAP for local release of naproxen at adequate concentrations. Kinetic modeling showed that the naproxen release process was closely related to the Higuchi model, which considers the drug release as a diffusional process based on Fick's law. The chemical stability of NAP after the release tests was verified by H-1 NMR. The {[}Mg-Al]-LDH/NAP also exhibited low cytotoxicity toward fibroblast cells (L929 cell line), without modifications in their morphology and adhesion capacity. These results describe a suitable approach for preparing efficient systems for local delivery of nonsteroidal anti-inflammatory drugs for biomedical applications. (AU)

FAPESP's process: 18/07860-9 - Development of nanocomposite polymer filaments with anti-inflammatory properties for 3D printing as bone substituent
Grantee:Marcela Piassi Bernardo
Support type: Scholarships in Brazil - Post-Doctorate