Potential properties of L-Asparagine for ESR dosimetry applications

Author(s)

Lima, Iara S. ^[1] ; Guidelli, Eder J. ^[1] ; Baffa, Oswaldo ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Fis, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Radiation Physics and Chemistry; v. 180, MAR 2021.
• Web of Science Citations: 0

Abstract

Radiation-induced free radicals in x-ray irradiated L-asparagine have been investigated by Electron Spin Resonance (ESR) spectroscopy, for dosimetric purposes. Optimal signal-to-noise (S/N) ratio and signal intensity for ESR spectra were found for a microwave power of 2 mW, and modulation amplitude of 1 mT. The dosimetric properties of L-asparagine are characterized by a linear dose-response in the therapeutic dose range, and lowest detectable dose was 0.1 Gy, including a small energy dependence (80 KV-6 MV), dose rate independence over a range of clinical relevance (100-600 cGy/min). The ESR signal stability was also investigated in the period of 6 months at room temperature. No changes in the signal intensity were observed over this period. Therefore, we propose L-asparagine as a potential candidate for electron spin resonance dosimetry of ionizing radiation. (AU)

• FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
• Grantee: Oswaldo Baffa Filho
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC