Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Predictive factors for the development of anemia after hematopoietic stem cell donation

Full text
Steuer, Lia V. [1] ; Kondo, Andrea T. [1] ; Cipolletta, Andrea N. [1] ; Sakashita, Araci M. [1] ; Hamerschlak, Nelson [1] ; Kutner, Jose M. [1]
Total Authors: 6
[1] Hosp Israelita Albert Einstein, Hemotherapy & Cell Therapy Dept, Av Albert Einstein 627, Banco Sangue, Bloco A-3, BR-05651901 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Transfusion; v. 61, n. 1, p. 159-166, JAN 2021.
Web of Science Citations: 0

Background Although Hematopoietic Stem Cells (HSC) donation through bone marrow (BM) and peripheral blood (PB) are usually safe procedures, adverse events are expected. One of the most common events especially among BM donors (BMD) is the development of anemia. To protect the BMD and preserve the hemoglobin levels, many centers collect autologous pre-procedure blood, but the actual benefits of this procedure is controversial. Methods and Materials This study analyzed retrospectively data to observe what factors may influence the occurrence of post-donation anemia and also evaluate the relevance of autologous red blood cell pre procedure donation (PAD). Results The development of immediately post donation anemia (IP) was higher in BMD than in PB donors (64.2% BMD and 10.7% PBD,P< .001) and also in late post donation (LP) (28.4% BMD and 3.6% PBD,P= .007). The study demonstrated an association between PAD and anemia in IP (72.7% with anemia and 27.3% without anemia,P= .006) and an association between the volume of red blood cells in the donated hematopoietic product and the development of anemia in LP (356.3 mL and 297.8 mL,P= .037). Conclusion In conclusion, collection of HSC through BM is a risk factor for anemia and PAD is a risk factor for IP anemia. (AU)

FAPESP's process: 17/05694-1 - Predictive factors for the development of anemia post-hematopoietic stem cell donations
Grantee:Lia Vineyard Steuer
Support type: Scholarships in Brazil - Scientific Initiation