Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy

Full text
Author(s):
Vogel, Debora D. S. [1] ; Ortiz-Villatoro, Nancy N. [1] ; de Freitas, Leandro [1] ; Aimbire, Flavio [2] ; Scorza, Fulvio A. [1] ; Albertini, Regiane [3] ; Scorza, Carla A. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Escola Paulista Med EPM, Disciplina Neurociencia, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Med Translac, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Ciencia Movimento Humano & Reabi, i, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biophotonics; v. 14, n. 1 JAN 2021.
Web of Science Citations: 0
Abstract

Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for therapeutic interventions during epileptogenesis for better long-term disease outcomes. Transcranial photobiomodulation (PBM) and omega-3 (omega-3) dietary supplementation are two approaches that have been shown promising neuroprotective effects after brain injuries. Here, we studied the PBM treatment or omega-3 diet during epileptogenesis in long-term recurrent spontaneous abnormal electrical discharges after stroke. Wistar rats received repetitive 780 nm-laser in the scalp or oral diet with omega-3 for 2-months after photothrombotic stroke. EEG recordings were performed 60 days after treatment end. PBM but not omega-3 reduced both electrographic seizure duration and spikes number in the ipsilateral and contralateral cortices and ventral posteromedial thalamic nucleus. Conclusively, PBM reduced epileptiform discharges in stroke-induced epilepsy. Our results suggest the PBM as a therapeutic approach for stroke-induced epileptogenesis to minimize long-term disease outcomes. (AU)

FAPESP's process: 16/10286-7 - Supplementation Paper Assessment with Omega -3 and laser therapy of low intensity in the Thalamus in Experimental Model of Ischemic Stroke
Grantee:Regiane Albertini de Carvalho
Support type: Regular Research Grants