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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy

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Vogel, Debora D. S. [1] ; Ortiz-Villatoro, Nancy N. [1] ; de Freitas, Leandro [1] ; Aimbire, Flavio [2] ; Scorza, Fulvio A. [1] ; Albertini, Regiane [3] ; Scorza, Carla A. [1]
Total Authors: 7
[1] Univ Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Escola Paulista Med EPM, Disciplina Neurociencia, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Med Translac, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Ciencia Movimento Humano & Reabi, i, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biophotonics; v. 14, n. 1 JAN 2021.
Web of Science Citations: 0

Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for therapeutic interventions during epileptogenesis for better long-term disease outcomes. Transcranial photobiomodulation (PBM) and omega-3 (omega-3) dietary supplementation are two approaches that have been shown promising neuroprotective effects after brain injuries. Here, we studied the PBM treatment or omega-3 diet during epileptogenesis in long-term recurrent spontaneous abnormal electrical discharges after stroke. Wistar rats received repetitive 780 nm-laser in the scalp or oral diet with omega-3 for 2-months after photothrombotic stroke. EEG recordings were performed 60 days after treatment end. PBM but not omega-3 reduced both electrographic seizure duration and spikes number in the ipsilateral and contralateral cortices and ventral posteromedial thalamic nucleus. Conclusively, PBM reduced epileptiform discharges in stroke-induced epilepsy. Our results suggest the PBM as a therapeutic approach for stroke-induced epileptogenesis to minimize long-term disease outcomes. (AU)

FAPESP's process: 16/10286-7 - Supplementation Paper Assessment with Omega -3 and laser therapy of low intensity in the Thalamus in Experimental Model of Ischemic Stroke
Grantee:Regiane Albertini de Carvalho
Support type: Regular Research Grants