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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Despite increasing aldosterone, elevated potassium is not necessary for activating aldosterone-sensitive HSD2 neurons or sodium appetite

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Author(s):
Fazan, Frederico S. [1, 2] ; Colombari, Eduardo [1] ; Loewy, Arthur D. [3] ; Geerling, Joel C. [2]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, Dept Physiol & Pathol, Araraquara, SP - Brazil
[2] Univ Iowa Hosp & Clin, Dept Neurol, Iowa Neurosci Inst, Iowa City, IA 52242 - USA
[3] Washington Univ, Dept Neurosci, Sch Med St Louis, St Louis, MO 63110 - USA
Total Affiliations: 3
Document type: Journal article
Source: PHYSIOLOGICAL REPORTS; v. 9, n. 2 JAN 2021.
Web of Science Citations: 0
Abstract

Restricting dietary sodium promotes sodium appetite in rats. Prolonged sodium restriction increases plasma potassium (pK), and elevated pK is largely responsible for a concurrent increase in aldosterone, which helps promote sodium appetite. In addition to increasing aldosterone, we hypothesized that elevated potassium directly influences the brain to promote sodium appetite. To test this, we restricted dietary potassium in sodium-deprived rats. Potassium restriction reduced pK and blunted the increase in aldosterone caused by sodium deprivation, but did not prevent sodium appetite or the activation of aldosterone-sensitive HSD2 neurons. Conversely, supplementing potassium in sodium-deprived rats increased pK and aldosterone, but did not increase sodium appetite or the activation of HSD2 neurons relative to potassium restriction. Supplementing potassium without sodium deprivation did not significantly increase aldosterone and HSD2 neuronal activation and only modestly increased saline intake. Overall, restricting dietary sodium activated the HSD2 neurons and promoted sodium appetite across a wide range of pK and aldosterone, and saline consumption inactivated the HSD2 neurons despite persistent hyperaldosteronism. In conclusion, elevated potassium is important for increasing aldosterone, but it is neither necessary nor sufficient for activating HSD2 neurons and increasing sodium appetite. (AU)

FAPESP's process: 19/09820-7 - Effects of systemic hyperkalemia: neural HSD2 activation and water balance
Grantee:Frederico Sassoli Fazan
Support Opportunities: Scholarships abroad - Research Internship - Master's degree