| Full text | |
| Author(s): Show less - |
Brondani, Vania Balderrama
[1]
;
Lacombe, Amanda Meneses Ferreira
[1]
;
Mariani, Beatriz Marinho de Paula
[2]
;
Montenegro, Luciana
[2, 3]
;
Soares, Ibere Cauduro
[4, 5]
;
Bezerra-Neto, Joao Evangelista
[6]
;
Tanno, Fabio Yoshiaki
[7]
;
Srougi, Victor
[7]
;
Chambo, Jose Luis
[7]
;
Mendonca, Berenice Bilharinho
[1, 2, 3]
;
Almeida, Madson Q.
[1, 2, 8]
;
Zerbini, Maria Claudia Nogueira
[4]
;
Fragoso, Maria Candida Barisson Villares
[1, 2, 8]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Unidade Suprarrenal, Serv Endocrinol & Metabol, Hosp Clin, Av Dr Eneas Carvalho Aguiar 155, BR-05403900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Hormonios & Genet Mol LIM 42, Av Dr Eneas Carvalho Aguiar 255, BR-05403900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Lab Sequenciamento Larga Escala SELA, Av Dr Arnaldo 455, BR-01246903 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Patol, Av Dr Arnaldo 455, BR-01246903 Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Serv Anat Patol, Inst Canc Estado Sao Paulo ICESP, Av Dr Arnaldo 251, BR-01246000 Sao Paulo - Brazil
[6] Univ Sao Paulo, Fac Med, Serv Oncol, Inst Canc Estado Sao Paulo ICESP, Av Dr Arnaldo 251, BR-01246000 Sao Paulo - Brazil
[7] Univ Sao Paulo, Fac Med, Serv Urol, Hosp Clin, Av Dr Eneas Carvalho Aguiar 155, BR-05403900 Sao Paulo - Brazil
[8] Univ Sao Paulo, Fac Med, Serv Endocrinol, Inst Canc Estado Sao Paulo ICESP, Av Dr Arnaldo 251, BR-01246000 Sao Paulo - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 3 FEB 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of ATRX and ZNRF3 genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of ATRX and ZNRF3 in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of ATRX and ZNRF3 was associated with a decrease in overall survival (OS) (p = 0.045, p = 0.012, respectively). The Cox regression for ATRX protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997; p = 0.049) when compared with <= 1.5; for ZNRF3 expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852; p = 0.015) when compared with <= 2. High ATRX and ZNRF3 protein expressions were associated with optimistic recurrence-free survival (RFS) (p = 0.027 and p = 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for ATRX expression >2.7 (p = 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for ZNRF3 expression >2 (p = 0.013). In conclusion, low protein expression of ATRX and ZNRF3 are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings. (AU) | |
| FAPESP's process: | 17/26345-5 - Evaluation of prognostic factors of adrenal cortex tumors and predictors of response to treatment with mitotane in carcinomas |
| Grantee: | Maria Candida Barisson Villares Fragoso |
| Support Opportunities: | Regular Research Grants |