| Full text | |
| Author(s): Show less - |
Saldanha, Nanci Moreira
[1]
;
Suemoto, Claudia Kimie
[1]
;
Rodriguez, Roberta Diehl
[1]
;
Leite, Renata Elaine Paraizo
[1]
;
Nascimento, Camila
[1]
;
Ferreti-Rebustini, Renata
[2, 3, 1]
;
da Silva, Magnolia Moreira
[2, 3, 1]
;
Pasqualucci, Carlos Augusto
[1]
;
Nitrini, Ricardo
[1]
;
Jacob-Filho, Wilson
[1]
;
Lafer, Beny
[1]
;
Grinberg, Lea T.
[3, 1]
;
Nunes, Paula Villela
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Escola Enfermagem, Sao Paulo, SP - Brazil
[3] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 - USA
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Affective Disorders; v. 278, p. 372-381, JAN 1 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: : Depression has been associated with dementia. This study aimed to verify if 13-amyloid Alzheimer's disease-type burden was associated with lifetime major depressive disorder (MDD) and with current depressive symptoms in a large population-based autopsy study. Methods: : We included 1013 deceased subjects submitted to autopsy (mean age=74.3 +/- 11.6 years, 49% men) in a community sample. 13-amyloid burden was measured in all cases based on the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria for presence and density of neuritic plaques. Lifetime MDD was defined when at least one previous episode according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders - DSM (SCID). Depressive symptoms and cognitive impairment were determined using the depression item of the Neuropsychiatric Inventory (D-NPI>0) and the Clinical Dementia Rating scale (CDR>0.5) respectively. Results: : Lifetime MDD, late life depression (LLD) and current depressive symptoms were associated with cognitive impairment (p<0.001). Additionally, neuritic plaques were associated with cognitive impairment (p<0.001). Moderate or frequent neurite plaque density was not associated with MDD, LLD or current depressive symptoms in multiple logistic models adjusted for age, gender, and cognitive impairment. Limitations:: In this cross-sectional study, all neuropsychiatric and cognitive assessment were based on informant-report of deceased participants. Conclusions: : Different clinical depictions of depression were associated with dementia in this large community sample of elderly individuals with multiethnic backgrounds. Notwithstanding, they were unrelated to 13-amyloid pathology in the brain areas studied. The link between depression and dementia might be complex and determined by multiple factors. (AU) | |
| FAPESP's process: | 16/24326-0 - Characterization of tau astrogliopathy on aging and neurodegenerative diseases |
| Grantee: | Roberta Diehl Rodriguez |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/07089-8 - Investigating TDP-43 as neuromarker of Bipolar Disorder |
| Grantee: | Camila Nascimento Mantelli |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |