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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiorespiratory effects of tiletamine-zolazepan in hypovolemic dogs

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Author(s):
C.A.A. Valadão [1] ; C.E. Pacchini [2]
Total Authors: 2
Affiliation:
[1] Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias
[2] Universidade de Marília
Total Affiliations: 2
Document type: Journal article
Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 53, n. 1, p. 44-51, 2001-02-00.
Abstract

Cardiovascular alterations were studied in 14 mongrel dogs divided into two groups (A n=7 control; B n=7, with hypovolemic dogs) under sevoflurane anesthesia (0.5 minimal alveolar concentration - MAC). Thirty minutes after the induction, blood was removed from right femural artery, equivalent to 30ml/bw (body weight). Thirty minutes past bleeding 10 mg/kg tiletamine-zolazepan (TZ) were given intravenously. No changes were noticed in heart rate, arterial blood pressure and cardiac output but TZ had induced transitory apnea immediately after injection. It was observed that tiletamine- zolazepan produced transitory breathing depression and it seems that it do not induce significant cardiovascular changes in hypovolemic dogs. (AU)