Nerve Growth Factor-Induced Sensitization of the Sternocleidomastoid Muscle and Its Effects on Trigeminal Muscle Sensitivity and Pain Profiles: A Randomized Double-Blind Controlled Study

Author(s)

de Caxias, Fernanda Pereira ^[1] ; Exposto, Fernando Gustavo ^{[2, 3]} ; Leal Turcio, Karina Helga ^[1] ; dos Santos, Daniela Micheline ^[1] ; Svensson, Peter ^{[4, 3]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Dent Mat & Prosthodont, Aracatuba - Brazil

^[2] Scandinavian Ctr Orofacial Neurosci SCON, Aarhus - Denmark

^[3] Aarhus Univ, Fac Hlth, Dept Dent, Sect Orofacial Pain & Jaw Funct, Aarhus - Denmark

^[4] Karolinska Inst, Dept Dent Med, Huddinge - Sweden

• Document type: Journal article
• Source: JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE; v. 35, n. 1, p. 7-16, WIN 2021.
• Web of Science Citations: 0

Abstract

Aims: To investigate whether localized sensitization of the sternocleidomastoid (SCM) muscle using nerve growth factor (NGF) would affect masseter and anterior temporalis muscle sensitivity and pain profiles. Methods: A total of 28 healthy participants attended two sessions (T-0 and T-1). At T-0, the maximum voluntary occlusal bite force (MVOBF), as well as pressure pain thresholds (PPT), mechanical sensitivity, and referred pain/sensations for the SCM, masseter, and temporalis muscles, were assessed. Participants also completed the Pain Catastrophizing Scale (PCS), the Pain Vigilance and Awareness Questionnaire (PVAQ), and the Neck Disability Index (NDI). After these assessments, 14 participants received an injection of NGF into the SCM, and 14 received an injection of isotonic saline solution. At T-1 (48 hours postinjection), the participants were again submitted to the same evaluations. Results: NGF caused significant mechanical sensitization in the SCM (P < .025), but not in the masseter or temporalis muscles (P > .208). It also caused significant increases in NDI score (P = .004). No statistically significant differences were found for MVOBF, frequency of referred pain/sensations, or questionnaire scores (P > .248). Conclusion: These results suggest that 48 hours after localized sensitization of the SCM, the primary response is impairment of neck function, but not jaw function. (AU)

• FAPESP's process: 18/00770-4 - Hypervigilance and experimental pain in the neck. Their effects on pain threshold, electrical activity of masticatory muscles, fatigue sensation and pain expectation.
• Grantee: Fernanda Pereira de Caxias
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate