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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fish Oil Enriched in EPA, but Not in DHA, Reverses the Metabolic Syndrome and Adipocyte Dysfunction Induced by a High-Fat Diet

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Author(s):
Cavalcante da Cunha de Sa, Roberta Dourado [1] ; Simao, Jussara de Jesus [1] ; da Silva, Viviane Simoes [1] ; de Farias, Talita Mendes [1] ; Cruz, Maysa Mariana [1] ; Antraco, Vitor Jaco [1] ; Armelin-Correa, Lucia [1] ; Alonso-Vale, Maria Isabel [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, UNIFESP, BR-09913030 Diadema - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NUTRIENTS; v. 13, n. 3 MAR 2021.
Web of Science Citations: 0
Abstract

This study aimed to investigate the effects of two commercially available fish oils (FOs) containing different proportions of two omega-3 fatty acids (FA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the metabolic and endocrine dysfunctions of white adipose tissue resulting from obesity. Male C57BL/6J mice, 8 weeks old, received a control or high-fat diet (CO and HF groups, with 9% and 59% energy from fat, respectively) for 8 weeks. The next 8 weeks, the HF group was subdivided into HF, HF+FO/E (HF+5:1 EPA:DHA), and HF+FO/D (HF+5:1 DHA:EPA). Supplementation was performed by gavage, three times a week. All groups that received the HF diet had lower food and caloric intake, but a higher fat intake, body weight (BW) gain, glucose intolerance, and a significant increase in inguinal (ING), retroperitoneal (RP), and epididymal (EPI) adipose tissues when compared to the CO group. Additionally, HF and HF+FO/D groups showed insulin resistance, adipocyte hypertrophy, increased lipolysis and secretion of TNF-alpha, resistin and IL-10 adipokines by ING and RP adipocytes, and adiponectin only by the HF+FO/D group in ING adipocytes. All of these effects were completely reversed in the HF+FO/E group, which also showed partial reversion in BW gain and glucose intolerance. Both the HF+FO/E and HF+FO/D groups showed a reduction in ING and RP adipose depots when compared to the HF group, but only HF+FO/E in the EPI depot. HF+FO/E, but not HF+FO/D, was able to prevent the changes triggered by obesity in TNF-alpha, Il-10, and resistin secretion in ING and RP depots. These results strongly suggest that different EPA:DHA ratios have different impacts on the adipose tissue metabolism, FO being rich in EPA, but not in DHA, and effective in reversing the changes induced by obesity. (AU)

FAPESP's process: 17/08582-0 - Effects of treatment wih fish oil on metabolic and endocrine dysfunction of adipocytes isolated from animals with metabolic syndrome
Grantee:Roberta Dourado Cavalcante da Cunha de Sá
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/05485-6 - Effects of high fat diet and supplementation with omega-7 and omega-3 fatty acids on the browning process, proliferation and differentiation of mesenchymal cells contained in the stromal cell fraction from adipose tissue
Grantee:Maria Isabel Cardoso Alonso-Vale
Support type: Regular Research Grants