| Full text | |
| Author(s): Show less - |
Limongi Franca Guilherme, Joao Paulo
[1]
;
Semenova, Ekaterina A.
[2, 3]
;
Zempo, Hirofumi
[4]
;
Martins, Gabriel L.
[1]
;
Lancha Junior, Antonio H.
[1]
;
Miyamoto-Mikami, Eri
[5]
;
Kumagai, Hiroshi
[5, 6]
;
Tobina, Takuro
[7]
;
Shiose, Keisuke
[8]
;
Kakigi, Ryo
[9]
;
Tsuzuki, Takamasa
[10]
;
Ichinoseki-Sekine, Noriko
[5, 11]
;
Kobayashi, Hiroyuki
[12]
;
Naito, Hisashi
[5]
;
Borisov, V, Oleg
;
Kostryukova, Elena S.
[13]
;
Kulemin, Nikolay A.
[13]
;
Larin, Andrey K.
[13]
;
Generozov, V, Edward
;
Fuku, Noriyuki
[5]
;
Ahmetov, Ildus I.
[14, 15, 16, 17]
Total Authors: 21
|
| Affiliation: Show less - | [1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Sao Paulo - Brazil
[2] Kazan Fed Univ, Dept Biochem, Kazan - Russia
[3] V, Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, Dept Mol Biol & Genet, Moscow - Russia
[4] Tokyoseiei Coll, Fac Hlth & Nutr, Katsushika City, Tokyo - Japan
[5] Juntendo Univ, Grad Sch Hlth & Sports Sci, Chiba - Japan
[6] Japanese Soc Promot Sci, Tokyo - Japan
[7] Univ Nagasaki, Fac Nursing & Nutr, Nagasaki - Japan
[8] Univ Miyazaki, Fac Educ, Miyazaki - Japan
[9] Juntendo Univ, Fac Med, Tokyo - Japan
[10] Meijo Univ, Fac Pharm, Nagoya, Aichi - Japan
[11] Open Univ Japan, Fac Liberal Arts, Chiba - Japan
[12] Tsukuba Univ Hosp, Mito Med Ctr, Dept Gen Med, Tsukuba, Ibaraki - Japan
[13] Borisov, Oleg, V, V, Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, Dept Mol Biol & Genet, Moscow - Russia
[14] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England
[15] Kazan State Med Univ, Lab Mol Genet, Kazan - Russia
[16] St Petersburg Res Inst Phys Culture, Sports Genet Lab, St Petersburg - Russia
[17] Plekhanov Russian Univ Econ, Dept Phys Educ, Moscow - Russia
Total Affiliations: 17
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE; v. 16, n. 4, p. 489-495, APR 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Purpose: To replicate previous genome-wide association study identified sprint-related polymorphisms in 3 different cohorts of top-level sprinters and to further validate the obtained results in functional studies. Methods: A total of 240 Japanese, 290 Russians, and 593 Brazilians were evaluated in a case-control approach. Of these, 267 were top-level sprint/power athletes. In addition, the relationship between selected polymorphisms and muscle fiber composition was evaluated in 203 Japanese and 287 Finnish individuals. Results: The G allele of the rs3213537 polymorphism was overrepresented in Japanese (odds ratio {[}OR]: 2.07, P=.024) and Russian (OR: 1.93, P=.027) sprinters compared with endurance athletes and was associated with an increased proportion of fast-twitch muscle fibers in Japanese (P=.02) and Finnish (P=.041) individuals. A meta-analysis of the data from 4 athlete cohorts confirmed that the presence of the G/G genotype rather than the G/A+A/A genotypes increased the OR of being a sprinter compared with controls (OR: 1.49, P=.01), endurance athletes (OR: 1.79, P=.001), or controls + endurance athletes (OR: 1.58, P=.002). Furthermore, male sprinters with the G/G genotype were found to have significantly faster personal times in the 100-m dash than those with G/A+A/A genotypes (10.50 {[}0.26] vs 10.76 {[}0.31], P=.014). Conclusion: The rs3213537 polymorphism found in the CPNE5 gene was identified as a highly replicable variant associated with sprinting ability and the increased proportion of fast-twitch muscle fibers, in which the homozygous genotype for the major allele (ie, the G/G genotype) is preferable for performance. (AU) | |
| FAPESP's process: | 12/22516-6 - Polygenic profile of Brazilian athletes: distribution of polymorphisms associated with physical performance |
| Grantee: | João Paulo Limongi França Guilherme |
| Support Opportunities: | Scholarships in Brazil - Doctorate |