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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Platelet activating factor in the eye: Physiological roles, diseases and future perspectives

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Dalmaso, Barbara [1] ; da Silva-Junior, Ildefonso Alves [2] ; Fragel-Madeira, Lucianne [3] ; Jancar, Sonia [2] ; Debbio, Carolina Beltrame Del [1]
Total Authors: 5
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Cell & Dev Biol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Biomed Sci Inst, Dept Immunol, Sao Paulo - Brazil
[3] Fluminense Fed Univ, Inst Biol, Dept Neurobiol, Rio De Janeiro - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Prostaglandins & Other Lipid Mediators; v. 153, APR 2021.
Web of Science Citations: 0

Platelet Activating Factor (PAF) is a known phospholipid mediator of inflammation. Since its first description in 1972, it has emerged as a key regulator of vital cellular signaling functions, as proliferation, cell adhesion, and apoptosis. Evidence suggests that interactions between PAF and its receptor (PAFR) play a critical role in nervous system tissues, including the retina. The retina is a very important constituent of the visual system, along with the cornea, sclera, choroid, iris, and ciliary body, that acts synergistically to provide vision and to maintain optical homeostasis. There is evidence that PAF may regulate a wide range of physiological functions in the visual system tissues, such as eye development, inflammation, epithelial wound healing, and synapsis. Due to their multiple functions, PAF and PAFR also have important pathological and clinical implications in ocular disorders such as Choroidal Neovascularization (CNV), Age Macular Degeneration, (AMD), Diabetic Retinopathy (DR), transplant responses, and pharmacological interactions. Studies with PAFR antagonists have shown promising results such as inhibition of neovascularization and chloroquine-induced retinopathies, as well as reducing inflammation and retinal cell death. Due to the importance of PAFR signaling in the visual system and ophthalmology research, this review aims to provide a general overview of current and future perspectives about PAF in eye biology (AU)

FAPESP's process: 19/08544-6 - The role of PAF receptor in retinal stem cell reprogramming
Grantee:Bárbara Dalmaso
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/24001-1 - MicroRNAs role in retinal stem cells regulation
Grantee:Carolina Beltrame Del Debbio
Support type: Research Grants - Young Investigators Grants