Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcranial direct current stimulation (tDCS) in the management of epilepsy: A systematic review

Full text
Author(s):
Sudbrack-Oliveira, Pedro [1, 2, 3] ; Barbosa, Marina Zanichelli [1, 2, 3] ; Thome-Souza, Sigride [4] ; Razza, Lais Boralli [1, 2, 3] ; Gallucci-Neto, Jose [5] ; Lane Valiengo, Leandro da Costa [1, 2, 3, 6] ; Brunoni, Andre Russowsky [7, 1, 2, 3, 8]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Med Sch, Serv Interdisciplinary Neuromodulat, Dept & Inst Psychiat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Lab Neurosci, Dept & Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Natl Inst Biomarkers Psychiat, Dept & Inst Psychiat, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept & Inst Psychiat, Video EEG Unit, Med Sch, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept & Inst Psychiat, Neuropsychiat Program, Med Sch, Sao Paulo - Brazil
[6] Univ Sao Paulo, Expt Physiopathol Program, Med Sch, Sao Paulo - Brazil
[7] Univ Sao Paulo, Interdisciplinary Ctr Appl Neuromodulat, Univ Hosp, Sao Paulo - Brazil
[8] Univ Sao Paulo, Ctr Clin & Epidemiol Res, Univ Hosp, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Review article
Source: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY; v. 86, p. 85-95, MAR 2021.
Web of Science Citations: 0
Abstract

Purpose: Current therapies for the management of epilepsy are still suboptimal for several patients due to inefficacy, major adverse events, and unavailability. Transcranial direct current stimulation (tDCS), an emergent non-invasive neuromodulation technique, has been tested in epilepsy samples over the past two decades to reduce either seizure frequency or electroencephalogram (EEG) epileptiform discharges. Methods: A systematic review was performed in accordance with PRISMA guidelines (PROSPERO record CRD42020160292). A thorough electronic search was completed in MEDLINE, EMBASE, CENTRAL and Scopus databases for trials that applied tDCS interventions to children and adults with epilepsy of any cause, from inception to April 30, 2020. Results: Twenty-seven studies fulfilled eligibility criteria, including nine sham-controlled and 18 uncontrolled trials or case reports/series. Samples consisted mainly of drug-resistant focal epilepsy patients that received cathodal tDCS stimulation targeted at the site with maximal EEG abnormalities. At follow-up, 84 % (21/25) of the included studies reported a reduction in seizure frequency and in 43 % (6/14) a decline in EEG epileptiform discharge rate was observed. No serious adverse events were reported. Conclusions: Cathodal tDCS is both a safe and probably effective technique for seizure control in patients with drug-resistant focal epilepsy. However, published trials are heterogeneous regarding samples and methodology. More and larger sham-controlled randomized trials are needed, preferably with mechanistic informed stimulation protocols, to further advance tDCS therapy in the management of epilepsy. (AU)

FAPESP's process: 19/07256-7 - Cerebral alteration perfusion induced by transcranial stimulation of the prefrontal cortex: a randomized, placebo-controlled study, using 99mTc SPECT
Grantee:Lais Boralli Razza
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/10760-9 - Circadian variability of motor cortex excitability in patients with Mesial Temporal Lobe Epilepsy: a Transcranial Magnetic Stimulation (TMS) study
Grantee:Pedro Sudbrack Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate