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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Colloidal Stability and Redispersibility of Mesoporous Silica Nanoparticles in Biological Media

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Schneid, Andressa da Cruz [1, 2] ; Silveira, Camila Pedroso [1, 2] ; Galdino, Flavia Elisa [1, 2, 3] ; Ferreira, Larissa Fernanda [1, 4] ; Bouchmella, Karim [5] ; Cardoso, Mateus Borba [1, 2, 3, 4]
Total Authors: 6
[1] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Nanotecnol LNNano, BR-13083970 Campinas, SP - Brazil
[2] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Luz Sincrotron LNLS, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas UNICAMP, Inst Quim IQ, BR-13083970 Campinas, SP - Brazil
[4] Univ Fed ABC, Pos Grad Biotecnociencia, BR-09210580 Santo Andre - Brazil
[5] Univ Montpellier, UMR 5253, Inst Charles Gerhardt Montpellier, CNRS, ENSCM, F-34095 Montpellier - France
Total Affiliations: 5
Document type: Journal article
Source: Langmuir; v. 36, n. 39, p. 11442-11449, OCT 6 2020.
Web of Science Citations: 3

The outreach of nanoparticle-based medical treatments has been severely hampered due to the imbalance between the efforts in designing extremely complex materials and the general lack of studies devoted to understanding their colloidal stability in biological environments. Over the years, the scientific community has neglected the relevance related to the nanoparticles' colloidal state, which consequently resulted in very poor bench-to-clinic translation. In this work, we show how mesoporous silica nanoparticles (MSNs, one of the most promising and tested drug delivery platforms) can be efficiently synthesized and prepared, resulting in a colloidally stable system. We first compared three distinct methods of template removal of MSNs and evaluated their ultimate colloidal stability. Then, we also proposed a simple way to prevent aggregation during the drying step by adsorbing BSA onto MSNs. The surface modification resulted in colloidally stable particles that are successfully redispersed in biologically relevant medium while retaining high hemocompatibility and low cytotoxicity. (AU)

FAPESP's process: 19/14007-3 - Double-functionalised silica nanoparticles for anti-bacterial effect
Grantee:Camila Pedroso Silveira Bueno
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/00763-8 - Synthesis of a Biodegradable Periodic Mesoporous Organosílica: A H. pylori Specific Drug Carrier
Grantee:Andressa da Cruz Schneid
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/09555-9 - Influence of protein corona on interaction and internalization of silica nanoparticles in human cells: from two-dimensional to tri-dimensional images
Grantee:Flávia Elisa Galdino
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/02145-7 - Study of the interaction between proteins and functionalized silica nanoparticles
Grantee:Larissa Fernanda Ferreira
Support Opportunities: Scholarships in Brazil - Master