Colloidal Stability and Redispersibility of Mesoporous Silica Nanoparticles in Biological Media

Author(s)

Schneid, Andressa da Cruz ^{[1, 2]} ; Silveira, Camila Pedroso ^{[1, 2]} ; Galdino, Flavia Elisa ^{[1, 2, 3]} ; Ferreira, Larissa Fernanda ^{[1, 4]} ; Bouchmella, Karim ^[5] ; Cardoso, Mateus Borba ^{[1, 2, 3, 4]}

Affiliation

^[1] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Nanotecnol LNNano, BR-13083970 Campinas, SP - Brazil

^[2] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Luz Sincrotron LNLS, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas UNICAMP, Inst Quim IQ, BR-13083970 Campinas, SP - Brazil

^[4] Univ Fed ABC, Pos Grad Biotecnociencia, BR-09210580 Santo Andre - Brazil

^[5] Univ Montpellier, UMR 5253, Inst Charles Gerhardt Montpellier, CNRS, ENSCM, F-34095 Montpellier - France

• Document type: Journal article
• Source: Langmuir; v. 36, n. 39, p. 11442-11449, OCT 6 2020.
• Web of Science Citations: 3

Abstract

The outreach of nanoparticle-based medical treatments has been severely hampered due to the imbalance between the efforts in designing extremely complex materials and the general lack of studies devoted to understanding their colloidal stability in biological environments. Over the years, the scientific community has neglected the relevance related to the nanoparticles' colloidal state, which consequently resulted in very poor bench-to-clinic translation. In this work, we show how mesoporous silica nanoparticles (MSNs, one of the most promising and tested drug delivery platforms) can be efficiently synthesized and prepared, resulting in a colloidally stable system. We first compared three distinct methods of template removal of MSNs and evaluated their ultimate colloidal stability. Then, we also proposed a simple way to prevent aggregation during the drying step by adsorbing BSA onto MSNs. The surface modification resulted in colloidally stable particles that are successfully redispersed in biologically relevant medium while retaining high hemocompatibility and low cytotoxicity. (AU)

• FAPESP's process: 19/14007-3 - Double-functionalised silica nanoparticles for anti-bacterial effect
• Grantee: Camila Pedroso Silveira Bueno
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/00763-8 - Synthesis of a Biodegradable Periodic Mesoporous Organosílica: A H. pylori Specific Drug Carrier
• Grantee: Andressa da Cruz Schneid
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/09555-9 - Influence of protein corona on interaction and internalization of silica nanoparticles in human cells: from two-dimensional to tri-dimensional images
• Grantee: Flávia Elisa Galdino
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/02145-7 - Study of the interaction between proteins and functionalized silica nanoparticles
• Grantee: Larissa Fernanda Ferreira
• Support Opportunities: Scholarships in Brazil - Master