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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

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Author(s):
Castro, Kelly A. D. F. [1] ; Costa, Leticia D. [2] ; Guieu, Samuel [3, 2] ; Biazzotto, Juliana C. [1] ; Neves, Maria da Graca P. M. S. [2] ; Faustino, M. Amparo F. [2] ; da Silva, Roberto S. [1] ; Tome, Augusto C. [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Sao Paulo, SP - Brazil
[2] Univ Aveiro, Dept Chem, LAQV REQUIMTE, Aveiro - Portugal
[3] Univ Aveiro, CICECO Aveiro Inst Mat, Dept Chem, Aveiro - Portugal
Total Affiliations: 3
Document type: Journal article
Source: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 19, n. 7, p. 885-891, JUL 2020.
Web of Science Citations: 0
Abstract

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most photo-toxic (at 2.5 mu M) towards B16F10 cells. (AU)

FAPESP's process: 16/12707-0 - Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug
Grantee:Roberto Santana da Silva
Support Opportunities: Regular Research Grants