| Full text | |
| Author(s): |
Brognara, Fernanda
[1, 2]
;
Felippe, Igor S. A.
[2]
;
Salgado, Helio C.
[1]
;
Paton, Julian F. R.
[2]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, 85 Pk Rd, Grafton Auckland 1023 - New Zealand
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | Cardiovascular Research; v. 117, n. 4, p. 1015-1032, APR 1 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The motivation for this review comes from the emerging complexity of the autonomic innervation of the carotid body (CB) and its putative role in regulating chemoreceptor sensitivity. With the carotid bodies as a potential therapeutic target for numerous cardiorespiratory and metabolic diseases, an understanding of the neural control of its circulation is most relevant. Since nerve fibres track blood vessels and receive autonomic innervation, we initiate our review by describing the origins of arterial feed to the CB and its unique vascular architecture and blood flow. Arterial feed(s) vary amongst species and, unequivocally, the arterial blood supply is relatively high to this organ. The vasculature appears to form separate circuits inside the CB with one having arterial venous anastomoses. Both sympathetic and parasympathetic nerves are present with postganglionic neurons located within the CB or close to it in the form of paraganglia. Their role in arterial vascular resistance control is described as is how CB blood flow relates to carotid sinus afferent activity. We discuss non-vascular targets of autonomic nerves, their possible role in controlling glomus cell activity, and how certain transmitters may relate to function. We propose that the autonomic nerves sub-serving the CB provide a rapid mechanism to tune the gain of peripheral chemoreflex sensitivity based on alterations in blood flow and oxygen delivery, and might provide future therapeutic targets. However, there remain a number of unknowns regarding these mechanisms that require further research that is discussed. (AU) | |
| FAPESP's process: | 18/16953-0 - The vascular and sympathetic innervation of the carotid body: is it altered in hypertension? |
| Grantee: | Fernanda Brognara Penteado Dias |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition |
| Grantee: | Helio Cesar Salgado |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/05163-6 - Role of the parasympathetic and sympathetic autonomic nervous system in the modulation of sepsis in unanesthetized rats |
| Grantee: | Fernanda Brognara Penteado Dias |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |