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Role of the parasympathetic and sympathetic autonomic nervous system in the modulation of sepsis in unanesthetized rats

Grant number: 17/05163-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2017
Effective date (End): April 30, 2020
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Helio Cesar Salgado
Grantee:Fernanda Brognara Penteado Dias
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition, AP.TEM
Associated scholarship(s):18/16953-0 - The vascular and sympathetic innervation of the carotid body: is it altered in hypertension?, BE.EP.DD


Neural pathways integrating the autonomic nervous system (sympathetic and parasympathetic) and the immune system have been described. One of them highlights the importance of parasympathetic activation inhibiting the innate immune response. Thus, considering that baroreflex activation elicits combined parasympathetic activity and sympathetic inhibition, the activation of the baroreflex may have play significant role modulating the inflammatory response. On the other hand, another proposes the regulation of the immune system by sympathetic activation. However, these neural mechanisms proposed have been originated from studies in anaesthetized animals (mice and rats). It is noteworthy that this project proposes to investigate, through experimental models in unanesthetized Wistar rats, the roles of the sympathetic and parasympathetic function in the modulation of systemic immune response induced by intravenous administration of lipopolysaccharide (LPS) extracted from Escherichia coli. To accomplish this, it is proposed to carry out protocols in unanesthetized rats receiving intravenous LPS as follows: 1) to investigate the role of the baroreflex, i.e. parasympathetic activation and sympathetic inhibition it is proposed to electrically stimulate the aortic depressor nerve; 2) to investigate the role of sympathetic activation, through baroreflex deactivation, it will be performed the bilateral carotid occlusion combined, or not, with the denervation of the carotid chemoreceptors and aortic baroreceptors; the pharmacological blockade of ²-adrenergic receptors with propranolol will be used as well. Therefore, it is expected that these protocols carried out in unanesthetized rats, will characterize the individual or combined participation of sympathetic and parasympathetic function in the modulation of systemic inflammatory response induced by LPS. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTANIA, JACI A.; KATAYAMA, PEDRO L.; BROGNARA, FERNANDA; MORAES, DAVI J. A.; SABINO, JOAO PAULO J.; SALGADO, HELIO C. Selective denervation of the aortic and carotid baroreceptors in rats. Experimental Physiology, v. 104, n. 9, p. 1335-1342, SEP 2019. Web of Science Citations: 0.
BROGNARA, FERNANDA; CASTANIA, JACI AIRTON; MARTINS DIAS, DANIEL PENTEADO; KANASHIRO, ALEXANDRE; SALGADO, HELIO CESAR. Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats. FRONTIERS IN PHYSIOLOGY, v. 10, JUN 25 2019. Web of Science Citations: 0.
BROGNARA, FERNANDA; CASTANIA, JACI A.; DIAS, DANIEL P. M.; LOPES, ALEXANDRE H.; FAZAN, JR., RUBENS; KANASHIRO, ALEXANDRE; ULLOA, LUIS; SALGADO, HELIO C. Baroreflex stimulation attenuates central but not peripheral inflammation in conscious endotoxemic rats. Brain Research, v. 1682, p. 54-60, MAR 1 2018. Web of Science Citations: 4.
FAZAN, FREDERICO SASSOLI; BROGNARA, FERNANDA; FAZAN JUNIOR, RUBENS; MURTA JUNIOR, LUIZ OTAVIO; VIRGILIO SILVA, LUIZ EDUARDO. Changes in the Complexity of Heart Rate Variability with Exercise Training Measured by Multiscale Entropy-Based Measurements. Entropy, v. 20, n. 1 JAN 2018. Web of Science Citations: 5.

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