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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential regulation of the release of tumor necrosis factor-alpha and of eicosanoids by mast cells in rat airways after antigen challenge

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Author(s):
Trezena, A. G. ; Silva, Z. L. da ; Oliveira Filho, R. M. ; Damazo, A. S. [4] ; Straus, A. H. ; Takahashi, H. K. ; Oliani, S. M. ; Lima, W. T. de
Total Authors: 8
Document type: Journal article
Source: Mediators of Inflammation; v. 1, n. 2, p. 237-246, jul. 2004.
Field of knowledge: Biological Sciences - Morphology
Abstract

Rat trachea display a differential topographical distribution of connective tissue mast cells (CTMC) and mucosal mast cells (MMC) that may imply regional differences in the release of allergic mediators such as tumor necrosis factor-á (TNF-x) and eicosanoids. To evaluate the role of CTMC and MMC for release of TNF-x and eicosanoids after allergenic challenge in distinct segments of rat trachea. OVA challenge induces TNF-x release from MMC, which is negatively regulated by CTMC. The profile of TNF-x and eicosanoids depends on the time after OVA challenge and of the tracheal segment considered. (AU)

FAPESP's process: 99/04228-7 - Neuroimmunomodulation: effects of stress and central nervous system acting drugs on immune/inflamatory response
Grantee:João Palermo Neto
Support type: Research Projects - Thematic Grants