Differential regulation of the release of tumor necrosis factor-alpha and of eicosanoids by mast cells in rat airways after antigen challenge

Author(s)

Trezena, A. G. ; Silva, Z. L. da ; Oliveira Filho, R. M. ; Damazo, A. S. ^[4] ; Straus, A. H. ; Takahashi, H. K. ; Oliani, S. M. ; Lima, W. T. de

• Document type: Journal article
• Source: Mediators of Inflammation; v. 1, n. 2, p. 237-246, jul. 2004.
• Field of knowledge: Biological Sciences - Morphology

Abstract

Rat trachea display a differential topographical distribution of connective tissue mast cells (CTMC) and mucosal mast cells (MMC) that may imply regional differences in the release of allergic mediators such as tumor necrosis factor-á (TNF-x) and eicosanoids. To evaluate the role of CTMC and MMC for release of TNF-x and eicosanoids after allergenic challenge in distinct segments of rat trachea. OVA challenge induces TNF-x release from MMC, which is negatively regulated by CTMC. The profile of TNF-x and eicosanoids depends on the time after OVA challenge and of the tracheal segment considered. (AU)

• FAPESP's process: 99/04228-7 - Neuroimmunomodulation: effects of stress and central nervous system acting drugs on immune/inflamatory response
• Grantee: João Palermo Neto
• Support type: Research Projects - Thematic Grants