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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia

Full text
Author(s):
Corsi-Zuelli, Fabiana [1] ; Deakin, Bill [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Div Psychiat, BR-14048900 Ribeirao Preto, SP - Brazil
[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Neurosci & Expt Psychol, Sch Biol Sci, Manchester M13 9PT, Lancs - England
Total Affiliations: 2
Document type: Journal article
Source: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 125, p. 637-653, JUN 2021.
Web of Science Citations: 0
Abstract

It is widely held that schizophrenia involves an active process of peripheral inflammation that induces or reflects brain inflammation with activation of microglia, the brain?s resident immune cells. However, recent in vivo radioligand binding studies and large-scale transcriptomics in post-mortem brain report reduced markers of microglial inflammation. The findings suggest a contrary hypothesis; that microglia are diverted into their noninflammatory synaptic remodelling phenotype that interferes with neurodevelopment and perhaps contributes to the relapsing nature of schizophrenia. Recent discoveries on the regulatory interactions between micro- and astroglial cells and immune regulatory T cells (Tregs) cohere with clinical omics data to suggest that: i) disinhibited astrocytes mediate the shift in microglial phenotype via the production of transforming growth factorbeta, which also contributes to the disturbances of dopamine and GABA function in schizophrenia, and ii) systemically impaired functioning of Treg cells contributes to the dysregulation of glial function, the low-grade peripheral inflammation, and the hitherto unexplained predisposition to auto-immunity and reduced lifeexpectancy in schizophrenia, including greater COVID-19 mortality. (AU)

FAPESP's process: 19/13229-2 - Inflammatory profile in the general population: transdiagnostic dimensions in the context of the psychosis continuum
Grantee:Fabiana Maria das Graças Corsi Zuelli
Support Opportunities: Scholarships in Brazil - Doctorate