Generation of 6 lines of human pluripotent stem cells from hypertensive patients and 3 lines of human pluripotent stem cell from normotensive patients

Author(s)

Sarafian, Raquel ^[1] ; Morato-Marques, Mariana ^[1] ; Borsoi, Juliana ^[1] ; Tofoli-Araujo, Fabiano ^[1] ; Pinheiro, Mara ^[2] ; Medina-Armenteros, Yordanka ^[1] ; Lotufo, Paulo A. ^[3] ; Bensenor, Isabela M. ^[3] ; Pereira, V, Lygia

Affiliation

^[1] V, Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Natl Lab Embryon Stem Cells LaNCE, BR-05508090 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, BR-05508090 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: STEM CELL RESEARCH; v. 53, MAY 2021.
• Web of Science Citations: 0

Abstract

Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences including cardiac insufficiency, stroke, dementia, chronic renal disease, ischemic heart disease and death. The hiPSC lines described here from six hypertensive patients and three controls were characterized according to established criteria and were shown to maintain pluripotency, differentiation into the three germ layers and genomic integrity. These cell lines can contribute to the understanding of the molecular mechanisms involved in hypertension in different cell types. (AU)

• FAPESP's process: 16/20650-8 - Assessment of hIPSC- derived hepatocytes as a model to study the responsiveness losartan in vitro
• Grantee: Raquel Delgado Sarafian
• Support Opportunities: Scholarships in Brazil - Master