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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension

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Pagan, Luana U. [1] ; Gomes, Mariana J. [1] ; Damatto, Ricardo L. [2] ; Lima, Aline R. R. [1] ; Cezar, Marcelo D. M. [2] ; Damatto, Felipe C. [1] ; Reyes, David R. A. [1] ; Campos, Dijon H. S. [1] ; Caldonazo, Tulio M. M. [1] ; Polegato, Bertha F. [1] ; Fernandes, Denise C. [3] ; Laurindo, Francisco R. [3] ; Fernandes, Ana A. H. [4] ; Lloret, Ana [5] ; Cicogna, Antonio C. [1] ; Okoshi, Marina P. [1] ; Okoshi, Katashi [1]
Total Authors: 17
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Botucatu, SP - Brazil
[2] FAIT, Itapeva Social & Agr Sci Coll, Itapeva - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Cardiopneumol, Sao Paulo - Brazil
[4] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil
[5] Univ Valencia, CIBERFES, INCLIVA, Freshage Res Grp, Dept Physiol, Valencia - Spain
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, JUN 3 2021.
Web of Science Citations: 0

Aim To evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-kappa B signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development. Methods We studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal-Wallis and Dunn tests. Results SHR-EX had a lower frequency of heart failure features than SHR. Myocardial function and antioxidant enzyme activity were better in SHR-EX than SHR. Lipid hydroperoxide concentration, and phosphorylated JNK and total IkB protein expression were higher in hypertensive than control groups. Malondialdehyde, NADPH oxidase activity, total JNK, phosphorylated p38, phosphorylated and total p65 NF-kappa B, and phosphorylated IkB did not differ between groups. Protein expression from total p38, and total and phosphorylated ERK were higher in SHR than W. Lactate dehydrogenase and phosphorylated ERK were lower and citrate synthase and beta-hydroxyacyldehydrogenase were higher in SHR-EX than SHR. Conclusion Exercise improves physical capacity, myocardial function, and antioxidant enzyme activity; reduces the frequency of heart failure features and ERK phosphorylation; and normalizes energy metabolism in SHR. (AU)

FAPESP's process: 15/17539-5 - Influence of physical exercise on cardiac remodeling, oxidative stress, and signaling of MAPK and NF-kB in spontaneously hypertensive rats
Grantee:Katashi Okoshi
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07048-2 - Influence of empagliflozin on the myocardium of rats with heart failure induced by aortic stenosis
Grantee:Luana Urbano Pagan
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/00747-1 - Influence of physical exercise on cardiac remodeling, oxidative stress, MAPK and NF-kB pathways signaling in spontaneously hypertensive rats
Grantee:Luana Urbano Pagan
Support Opportunities: Scholarships in Brazil - Doctorate