| Full text | |
| Author(s): |
de Carvalho, Ana Elisa T. S.
[1]
;
Cordeiro, Marco A.
[1]
;
Rodrigues, Luana S.
[1]
;
Ortolani, Daniela
[1]
;
Spadari, Regina C.
[1]
Total Authors: 5
|
| Affiliation: | [1] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Lab Stress Biol, Inst Hlth & Soc, Campus Baixada Santista, Rua Silva Jardim 136, BR-11020015 Santos, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 11, n. 1 APR 28 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (beta -AR) in the heart. Whether and how stress affects the expression of components of the intracellular environment in the heart is still, however, unknown. This paper used microarray to analyze the gene expression in the left ventricle wall of rats submitted to foot shock stress, treated or not treated with the selective beta (2)-AR antagonist ICI118,551 (ICI), compared to those of non-stressed rats also treated or not with ICI, respectively. The main findings were that stress induces changes in gene expression in the heart and that beta (2)-AR plays a role in this process. The vast majority of genes disregulated by stress were exclusive for only one of the comparisons, indicating that, in the same stressful situation, the profile of gene expression in the heart is substantially different when the beta (2)-AR is active or when it is blocked. Stress induced alterations in the expression of such a large number of genes seems to be part of stress-induced adaptive mechanism. (AU) | |
| FAPESP's process: | 16/20784-4 - The influence of sirtuins on beta adrenergic signaling pathway in the heart of rats submitted to stress |
| Grantee: | Ana Elisa Teófilo Saturi de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/20777-8 - The influence of sirtuins on beta 2 adrenergic pathway in heart of rats submitted to stress |
| Grantee: | Regina Celia Spadari |
| Support Opportunities: | Regular Research Grants |