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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Role of microRNAs in the Infection by T. gondii in Humans

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de Faria Junior, Geraldo Magela [1] ; Murata, Fernando Henrique Antunes [2] ; Lorenzi, Hernan Alejandro [3] ; Castro, Bruno Bello Pede [4] ; Assoni, Leticia Carolina Paraboli [1] ; Ayo, Christiane Maria [1] ; Brandao, Cinara Cassia [1] ; de Mattos, Luiz Carlos [1]
Total Authors: 8
[1] Fac Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Immunogenet Lab, Sao Jose Do Rio Preto - Brazil
[2] ARS, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, USDA, Beltsville, MD 20705 - USA
[3] J Craig Venter Inst, Dept Infect Dis, Rockville, MD - USA
[4] Univ Sao Paulo, Fac Vet Med, Dept Prevent Vet Med & Anim Hlth, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Review article
Web of Science Citations: 1

MicroRNAs are molecules belonging to an evolutionarily conserved family of small non-coding RNAs, which act on post-transcriptional gene regulation, causing messenger RNA (mRNA) degradation or inhibiting mRNA translation into proteins. These molecules represent potential biomarkers for diagnosis, non-invasive prognosis, and monitoring the development of the disease. Moreover, they may provide additional information on the pathophysiology of parasitic infections and guide strategies for treatment. The Apicomplexan parasite Toxoplasma gondii modifies the levels of microRNAs and mRNAs in infected host cells by modulating the innate and adaptive immune responses, facilitating its survival within the host. Some studies have shown that microRNAs are promising molecular markers for developing diagnostic tools for human toxoplasmosis. MicroRNAs can be detected in human specimens collected using non-invasive procedures. changes in the circulating host microRNAs have been associated with T. gondii infection in mice and ocular toxoplasmosis in humans. Besides, microRNAs can be amplified from samples using sensitive and molecular-specific approaches such as real-time PCR. This review presents recent findings of the role that microRNAs play during T. gondii infection and discuss their potential use of these small nuclei acid molecules to different approaches such as laboratory diagnosis, modulation of cell and tissue infected as other potential applications in human toxoplasmosis. (AU)

FAPESP's process: 18/09448-8 - Expression of miRNAs in ocular Toxoplasmosis
Grantee:Geraldo Magela de Faria Junior
Support type: Scholarships in Brazil - Doctorate