| Full text | |
| Author(s): Show less - |
Diaz-Garcia, Judith
[1, 2]
;
Arendrup, Maiken C.
[3, 4, 5]
;
Canton, Rafael
[6, 7, 8]
;
Garcia-Rodriguez, Julio
[9]
;
Garcia de la Pedrosa, Elia Gomez
[6, 7, 8]
;
Parisi, Gabriella
[10]
;
Peman, Javier
[11, 12]
;
Posteraro, Brunella
[13]
;
Sanguinetti, Maurizio
[14]
;
Da Matta, Daniel Archimedes
[15]
;
Colombo, Arnaldo L.
[15]
;
Munoz, Patricia
[1, 16, 2, 17]
;
Sanchez-Carrillo, Carlos
[1, 2, 17]
;
Guinea, Jesus
[1, 2, 17]
;
Escribano, Pilar
[1, 2]
Total Authors: 15
|
| Affiliation: Show less - | [1] Inst Invest Sanitaria Gregorio Maranon, Madrid - Spain
[2] Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Clin Microbiol & Infect Dis, Madrid - Spain
[3] Univ Copenhagen, Dept Clin Med, Copenhagen - Denmark
[4] Rigshosp, Dept Clin Microbiol, Copenhagen - Denmark
[5] StatensSerumInst, Unit Mycol, Copenhagen - Denmark
[6] Hosp Ramon & Cajal, Serv Microbiol, Madrid - Spain
[7] Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid - Spain
[8] Inst Salud Carlos III, Red Espanola Invest Patol Infecciosa REIPI, Madrid - Spain
[9] Hosp La Paz, Dept Clin Microbiol & Infect Dis, Madrid - Spain
[10] Azienda Osped San Camillo Forlanini, Rome - Italy
[11] Hosp Univ & Politecn La Fe, Valencia - Spain
[12] Inst Invest Sanitaria La Fe, Valencia - Spain
[13] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Gastroenterol Endocrino Metab &, Rome - Italy
[14] Fdn Policlin Univ A, Dipartimento Sci Lab & Infettivol, Gemelli IRCCS, Rome - Italy
[15] Univ Fed Sao Paulo, Special Lab Mycol, Sao Paulo - Brazil
[16] Univ Complutense Madrid, Fac Med, Med Dept, Madrid - Spain
[17] CIBER Enfermedades Resp CIBERES, CB06-06-0058, Madrid - Spain
Total Affiliations: 17
|
| Document type: | Journal article |
| Source: | REVISTA IBEROAMERICANA DE MICOLOGIA; v. 38, n. 1, p. 9-11, JAN-MAR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied. Aims: We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model. Methods: One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae. Results: The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5-2 vs. 2 days, IQR 1-2.25), C. parapsilosis (2 days, IQR 1.5-2.6 vs. 2 days, IQR 2-3.3), and C. tropicalis (1 day, IQR 1-3.5 vs. 2 days, IQR 2-3.5; p < 0.05). High intra-cluster variability in terms of median of survival was found regardless the species. Conclusions: No relationship between genotype and virulence in Candida was observed with the G. mellonella model. (C) 2020 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved. (AU) | |
| FAPESP's process: | 17/02203-7 - Multidisciplinary and international network to characterize microbiological aspects and natural history of invasive fungal infections due Candida spp |
| Grantee: | Arnaldo Lopes Colombo |
| Support Opportunities: | Research Projects - Thematic Grants |