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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Highlights Regarding the Use of Metallic Nanoparticles against Pathogens Considered a Priority by the World Health Organization

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Author(s):
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da Silva, Patricia Bento [1, 2] ; Sousa Araujo, Victor Hugo [1] ; Fonseca-Santos, Bruno [1] ; Solcia, Mariana Cristina [1] ; Ribeiro, Camila Maringolo [1] ; da Silva, Isabel Cristiane [1] ; Alves, Renata Carolina [1] ; Pironi, Andressa Maria [1] ; Lopes Silva, Ana Carolina [1] ; Victorelli, Francesca Damiani [1] ; Fernandes, Mariza Aires [1] ; Ferreira, Paula Scanavez [1] ; da Silva, Gilmar Hanck [1] ; Pavan, Fernando Rogerio [1] ; Chorilli, Marlus [1]
Total Authors: 15
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Univ Brasilia UnB, Inst Biol, Brasilia, DF - Brazil
Total Affiliations: 2
Document type: Review article
Source: Current Medicinal Chemistry; v. 28, n. 10, p. 1906-1956, 2021.
Web of Science Citations: 1
Abstract

The indiscriminate use of antibiotics has facilitated the growing resistance of bacteria, and this has become a serious public health problem worldwide. Several microorganisms are still resistant to multiple antibiotics and are particularly dangerous in the hospital and nursing home environment, and to patients whose care requires devices, such as ventilators and intravenous catheters. A list of twelve pathogenic genera, which especially included bacteria that were not affected by different antibiotics, was released by the World Health Organization (WHO) in 2017, and the research and development of new antibiotics against these genera has been considered a priority. The nanotechnology is a tool that offers an effective platform for altering the physical-chemical properties of different materials, thereby enabling the development of several biomedical applications. Owing to their large surface area and high reactivity, metallic particles on the nanometric scale have remarkable physical, chemical, and biological properties. Nanoparticles with sizes between 1 and 100 nm have several applications, mainly as new antimicrobial agents for the control of microorganisms. In the present review, more than 200 reports of various metallic nanoparticles, especially those containing copper, gold, platinum, silver, titanium, and zinc were analyzed with regard to their anti-bacterial activity. However, of these 200 studies, only 42 reported about trials conducted against the resistant bacteria considered a priority by the WHO. All studies are in the initial stage, and none are in the clinical phase of research. (AU)

FAPESP's process: 18/00163-0 - Development and search of new antimicrobials against Tuberculosis: from screening to pre-clinical studies in vivo
Grantee:Fernando Rogério Pavan
Support Opportunities: Regular Research Grants
FAPESP's process: 17/10016-2 - Liquid crystal precursor systems as a strategy for vaginal administration of CTT1 peptide: pharmacotechnical development and potential application for the treatment of cervical cancer
Grantee:Marlus Chorilli
Support Opportunities: Regular Research Grants
FAPESP's process: 13/14957-5 - Research potential against tuberculosis of a new class of furoxan compounds and nanostructured compounds of the ruthenium(II) and copper (II)
Grantee:Fernando Rogério Pavan
Support Opportunities: Research Grants - Young Investigators Grants