| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Fed Sao Paulo, UNIFESP, Dept Biol Sci, Campus Diadema, BR-09972270 Diadema, SP - Brazil
Total Affiliations: 1
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| Document type: | Review article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 12 JUN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Mammals face environmental stressors throughout their lifespan, which may jeopardize cellular homeostasis. Hence, these organisms have acquired mechanisms to cope with stressors by sensing, repairing the damage, and reallocating resources to increase the odds of long-term survival. Autophagy is a pro-survival lysosome-mediated cytoplasm degradation pathway for organelle and macromolecule recycling. Furthermore, autophagy efflux increases, and this pathway becomes idiosyncratic depending upon developmental and environmental contexts. Mammalian germ cells and preimplantation embryos are attractive models for dissecting autophagy due to their metastable phenotypes during differentiation and exposure to varying environmental cues. The aim of this review is to explore autophagy during mammalian gametogenesis, fertilization and preimplantation embryonic development by contemplating its physiological role during development, under key stressors, and within the scope of assisted reproduction technologies. (AU) | |
| FAPESP's process: | 17/20125-3 - Immediate and transgenerational epigenetic effects of heat stress on female gametes |
| Grantee: | Fabíola Freitas de Paula Lopes |
| Support Opportunities: | Research Program on Global Climate Change - Regular Grants |
| FAPESP's process: | 17/13082-6 - Oocyte responses to heat stress |
| Grantee: | Lais Barbosa Latorraca |
| Support Opportunities: | Scholarships in Brazil - Master |