Effects of renal denervation on cardiovascular, metabolic and renal functions in streptozotocin-induced diabetic rats

Author(s)

de Oliveira, Tales Lyra ^{[1, 2, 3]} ; Lincevicius, Gisele Silverio ^[2] ; Shimoura, Caroline Gusson ^{[2, 4]} ; Simoes-Sato, Alex Yuri ^[2] ; Garcia, Michelle Louvaes ^[2] ; Bergamaschi, Cassia T. ^[2] ; Campos, Ruy R. ^[2]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Inst Coracao, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Escola Paulista Med, Rua Botucatu 862, BR-04023060 Sao Paulo, SP - Brazil

^[3] Univ Municipal Sao Caetano do Sul, Med Sch, Sao Paulo - Brazil

^[4] Univ North Texas, Hlth Sci Ctr, Dept Physiol & Anat, Denton, TX 76203 - USA

• Document type: Journal article
• Source: Life Sciences; v. 278, AUG 1 2021.
• Web of Science Citations: 0

Abstract

Diabetes promotes renal sympathetic hyperactivity, autonomic imbalance, and cardiovascular and renal dysfunction. Bilateral renal denervation (BRD) has emerged as a treatment for diabetes; however, the mechanisms that underlie the beneficial effects of BRD are unknown. Aims: The present study evaluated the effects of BRD on autonomic, cardiovascular, metabolic, and renal function in streptozotocin-diabetic rats. Main methods: Wistar rats were separated into three experimental groups: control (CTR), diabetic (DM), and diabetic that underwent BRD (DM BRD). BRD was performed two weeks after STZ-diabetes induction, the experiments were performed four weeks after DM induction. This study evaluated sympathetic vasomotor nerve activity in different territories (renal, lumbar and splanchnic), arterial baroreceptor reflex, metabolic and renal function. Key findings: BRD significantly reduced glycemia, glycosuria, albuminuria, and SGLT2 gene expression in the kidney in DM rats. Renal sympathetic nerve activity (rSNA) was significantly increased and splanchnic sympathetic nerve activity (sSNA) was significantly decreased in DM rats, without changes in lumbar sympathetic nerve activity (lSNA). BRD was able to normalize sSNA and significantly increase lSNA in DM rats compared to control rats. Additionally, cardiac baroreceptor sensitivity was impaired in DM rats, and BRD significantly improved baroreflex sensitivity. Significance: Our data suggest that renal nerves play an important role in autonomic, cardiovascular, and renal dysfunction in STZ-DM rats. Thus, sympathetic renal hyperactivity should be considered a possible therapeutic target in diabetic patients. (AU)

• FAPESP's process: 14/26387-1 - MECHANISMS OF COMMUNICATION BETWEEN CENTRAL NERVOUS SYSTEM AND KIDNEY IN EXPERIMENTAL DIABETES MELLITUS
• Grantee: Tales Lyra de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/25295-0 - Communication between the central nervous system and kidneys: cardiovascular, renal and autonomic influences in physiological and physiopathological conditions
• Grantee: Ruy Ribeiro de Campos Junior
• Support Opportunities: Research Projects - Thematic Grants