Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential

Author(s)

Ferreira, Isabela Gobbo ^[1] ; Pucca, Manuela Berto ^[2] ; de Oliveira, Isadora Sousa ^[1] ; Cerni, Felipe Augusto ^[3] ; Jacob, Beatriz de Cassia da Silva ^[1] ; Arantes, Eliane Candiani ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Biomol Sci, Sch Pharmaceut Sci Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Roraima, Sch Med, Boa Vista, RR - Brazil

^[3] Univ Fed Roraima, Hlth Sci Postgrad Program, Boa Vista, RR - Brazil

• Document type: Review article
• Source: CYTOKINE & GROWTH FACTOR REVIEWS; v. 60, p. 133-143, AUG 2021.
• Web of Science Citations: 0

Abstract

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, a physiological process characterized by the formation of new vessels from a preexisting endothelium. VEGF has also been implicated in pathologic states, such as neoplasias, intraocular neovascular disorders, among other conditions. VEGFs are distributed in seven different families: VEGF-A, B, C, D, and PIGF (placental growth factor), which are identified in mammals; VEGF-E, which are encountered in viruses; and VEGF-F or svVEGF (snake venom VEGF) described in snake venoms. This is the pioneer review of svVEGF family, exploring its distribution among the snake venoms, molecular structure, main functions, and potential applications. (AU)

• FAPESP's process: 17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom
• Grantee: Isadora Sousa de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate