Altered brain creatine cycle metabolites in bipolar I disorder with childhood abuse: A H-1 magnetic resonance spectroscopy study

Author(s)

Bio, Danielle Soares ^[1] ; Moreno, Ricardo Alberto ^[1] ; Garcia-Otaduy, Maria Concepcion ^[2] ; Nery, Fabiano ^[3] ; Lafer, Beny ^[4] ; Soeiro-de-Souza, Marcio Gerhardt ^[5]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Psychiat, Mood Disorders Unit PROGRUDA, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Inst Radiol InRAD, Dept Radiol, Sao Paulo - Brazil

^[3] Univ Cincinnati, Med Ctr, Cincinnati, OH 45221 - USA

^[4] Univ Sao Paulo, Sch Med, Dept Psychiat, Bipolar Disorders Program PROMAN, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil

• Document type: Journal article
• Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 109, JUL 13 2021.
• Web of Science Citations: 0

Abstract

Background: Childhood abuse (CA) is a risk factor for a number of psychiatric disorders and has been associated with higher risk of developing bipolar disorders (BD). CA in BD has been associated with more severe clinical outcomes, but the neurobiological explanation for this is unknown. Few studies have explored in vivo measurement of brain metabolites using proton magnetic resonance spectroscopy (1H-MRS) in CA and no studies have investigated the association of CA severity with brain neurometabolites in BD. Objective: To investigate whether CA severity is associated with changes in anterior cingulate cortex (ACC) neurometabolite profile in BD and HC subjects. Methods: Fifty-nine BD I euthymic patients and fifty-nine HC subjects were assessed using the Childhood Trauma Questionnaire (CTQ) and underwent a 3-Tesla 1H-MRS scan. Severity of childhood abuse (physical, sexual and emotional) and its association with levels of brain metabolites was analyzed within each group. Results: BD patients had higher total scores on the CTQ and higher severity rates of sexual and physical abuse compared to HC subjects. Greater severity of physical and sexual abuse was associated with increased ACC PCr level and lower Cr/PCr ratio in the BD group only. Conclusion: Sexual and physical abuse in BD patients, but not in HC subjects, appeared to be associated with creatine metabolism in the ACC, which can influence neuronal mitochondrial energy production. Further studies should investigate whether this is the mechanism underlying the association between CA and worse clinical outcomes in BD. (AU)

• FAPESP's process: 14/03233-9 - The association between childhood trauma, cognitive functioning and brain morphology in patients with bipolar disorder type I
• Grantee: Danielle Soares Bio
• Support Opportunities: Scholarships in Brazil - Doctorate