| Full text | |
| Author(s): Show less - |
Nunes, Kelly
[1, 2]
;
Maia, Maria Helena Thomaz
[3]
;
dos Santos, Eduardo Jose Melo
[3]
;
dos Santos, Sidney Emanuel Batista
[3]
;
Guerreiro, Joao Farias
[3]
;
Petzl-Erler, Maria Luiza
[4]
;
Bedoya, Gabriel
[5]
;
Gallo, Carla
[6]
;
Poletti, Giovanni
[7]
;
Llop, Elena
[8]
;
Tsuneto, Luiza
[9]
;
Bortolini, Maria Catira
[10]
;
Rothhammer, Francisco
[11]
;
Single, Richard
;
Ruiz-Linares, Andres
[12, 13, 14]
;
Rocha, Jorge
[2, 15]
;
Meyer, Diogo
[1, 2, 16]
Total Authors: 17
|
| Affiliation: Show less - | [1] Univ Sao Paulo, Dept Genet & Biol Evolut, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Genet & Evolutionary Biol, BR-05508 Sao Paulo, SP - Brazil
[3] Univ Fed Para, Inst Ciencias Biol, Belem, Para - Brazil
[4] Univ Fed Parana, Dept Genet, Curitiba, Parana - Brazil
[5] Univ Antioquia, Inst Biol, Medellin - Colombia
[6] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Lima - Peru
[7] Univ Peruana Cayetano Heredia, Fac Med, Lima - Peru
[8] Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago - Chile
[9] Univ Estadual Maringa, Dept Ciencias Bas Saude, Maringa, Parana - Brazil
[10] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS - Brazil
[11] Univ Tarapaca, Inst Alta Invest, Arica - Chile
[12] Univ Vermont, Dept Math & Stat, Burlington, VT - USA
[13] Fudan Univ, Sch Life Sci & Human Phenome Inst, Collaborat Innovat Ctr Genet & Dev, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433 - Peoples R China
[14] D Aix Marseille Univ, CNRS, EFS, ADES, F-13007 Marseille - France
[15] Univ Porto, Fac Ciencias, Dept Biol, Porto - Portugal
[16] Univ Porto, Recursos Genet, CIBIO Ctr Invest Biodiversidade, Porto - Portugal
Total Affiliations: 16
|
| Document type: | Journal article |
| Source: | HUMAN IMMUNOLOGY; v. 82, n. 7, p. 523-531, JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from 30 human populations, 28 of which are Native Americans, all of whom were typed for genomewide and MHC region microsatellites. We find greater differentiation in the MHC than in the remainder of the genome (FST-MHC = 0.130 and FST-Genomic = 0.087), and use a permutation approach to show that this difference is statistically significant, and not accounted for by confounding factors. This finding lies in the opposite direction to the expectation that balancing selection reduces population differentiation. We interpret our findings as evidence that selection favors different sets of alleles in distinct localities, leading to increased differentiation. Thus, balancing selection at HLA genes simultaneously increases intrapopulation polymorphism and inter-population differentiation in Native Americans. (C) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 09/09127-8 - Molecular evolution and population genetics of HLA genes |
| Grantee: | Diogo Meyer |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/09950-9 - Evolution of HLA genes: population differentiation and signatures of recent selection in native and admixed populations from Brazil |
| Grantee: | Kelly Nunes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |