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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical Applications and Immunological Aspects of Electroporation-Based Therapies

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Author(s):
Luz, Jean Carlos dos Santos da [1] ; Antunes, Fernanda [1] ; Clavijo-Salomon, Maria Alejandra [2] ; Signori, Emanuela [3] ; Tessarollo, Nayara Gusmao [1] ; Strauss, Bryan E. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Canc Inst Sao Paulo, Viral Vector Lab, BR-01246000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Canc Inst Sao Paulo, Lab Expt Oncol, BR-01246000 Sao Paulo - Brazil
[3] CNR, Inst Translat Pharmacol, I-00133 Rome - Italy
Total Affiliations: 3
Document type: Review article
Source: VACCINES; v. 9, n. 7 JUL 2021.
Web of Science Citations: 1
Abstract

Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunological aspects involved in electrochemotherapy and gene electrotransfer, two important EP-based cancer therapies in human and veterinary oncology. (AU)

FAPESP's process: 17/25290-2 - A study of the role of neoantigens in the modulation of the anti-tumor response promoted by the treatment of B16 cells with p19Arf and IFN-beta.
Grantee:Nayara Gusmão Tessarollo
Support Opportunities: Scholarships in Brazil - Post-Doctoral